Troniz
Generic Name
Metronidazole
Manufacturer
Reputable Pharmaceutical Co. (Hypothetical)
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| troniz 500 mg tablet | ৳ 6.50 | ৳ 65.00 |
Description
Overview of the medicine
Troniz-500 mg tablet is an antibiotic and anti-protozoal medication containing Metronidazole, used to treat various bacterial and parasitic infections.
Uses & Indications
Dosage
Adults
Typically 500 mg orally 2-3 times daily, duration depends on infection type.
Elderly
No specific dose adjustment required, but caution in hepatic impairment.
Renal_impairment
Dose adjustment may be necessary in severe renal failure.
How to Take
Taken orally with or after food to minimize gastrointestinal upset.
Mechanism of Action
Metronidazole works by entering the bacterial or protozoal cells, where it is reduced to highly reactive nitro-free radicals. These radicals damage DNA and other cellular components, leading to cell death.
Pharmacokinetics
Onset
Typically within 24-48 hours for clinical effect.
Excretion
Mainly renal (60-80% of the dose) and to a lesser extent via feces.
Half life
Approximately 8 hours.
Absorption
Well absorbed orally, with peak plasma concentrations reached in 1-2 hours.
Metabolism
Primarily hepatic by hydroxylation and glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to metronidazole or other nitroimidazole derivatives
- First trimester of pregnancy (relative)
Drug Interactions
Alcohol
Disulfiram-like reaction (nausea, vomiting, flushing).
Lithium
Increases plasma lithium levels.
Warfarin
Potentiates anticoagulant effect.
Phenytoin/Phenobarbital
Decreased metronidazole efficacy.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, ataxia, and mild disorientation. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Generally avoided in the first trimester of pregnancy. Use with caution in later trimesters if benefits outweigh risks. Excreted into breast milk, caution advised.
Side Effects
Contraindications
- Hypersensitivity to metronidazole or other nitroimidazole derivatives
- First trimester of pregnancy (relative)
Drug Interactions
Alcohol
Disulfiram-like reaction (nausea, vomiting, flushing).
Lithium
Increases plasma lithium levels.
Warfarin
Potentiates anticoagulant effect.
Phenytoin/Phenobarbital
Decreased metronidazole efficacy.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, ataxia, and mild disorientation. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Generally avoided in the first trimester of pregnancy. Use with caution in later trimesters if benefits outweigh risks. Excreted into breast milk, caution advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Available in pharmacies worldwide
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have confirmed the efficacy and safety of Metronidazole in various bacterial and protozoal infections. Ongoing research explores new indications and resistance patterns.
Lab Monitoring
- Liver function tests (in prolonged therapy)
- Complete blood count (in prolonged therapy)
Doctor Notes
- Advise patients about potential disulfiram-like reaction with alcohol.
- Monitor for CNS toxicity (e.g., peripheral neuropathy, seizures) in prolonged or high-dose use.
- Educate patients on completing the full course to prevent resistance.
Patient Guidelines
- Complete the full course of medication even if symptoms improve.
- Avoid alcohol during treatment and for at least 3 days after stopping the medicine.
- Inform your doctor about any unusual side effects.
Missed Dose Advice
Take the missed dose as soon as you remember. If it's almost time for the next dose, skip the missed one and continue your regular schedule. Do not double dose.
Driving Precautions
Troniz may cause dizziness or visual disturbances. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good personal hygiene to prevent reinfection.
- Stay hydrated by drinking plenty of fluids.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.