Trospi
Generic Name
Trospium Chloride
Manufacturer
Generic Pharmaceuticals Inc.
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| trospi 20 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Trospium Chloride is an antimuscarinic agent used to treat overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency.
Uses & Indications
Dosage
Adults
20 mg orally twice daily or 60 mg extended-release once daily.
Elderly
Same as adults, but caution advised due to potential for renal impairment.
Renal_impairment
For moderate to severe renal impairment (CrCl < 30 mL/min), 20 mg once daily or 30 mg extended-release once daily is recommended.
How to Take
Take orally on an empty stomach at least one hour before a meal or two hours after a meal. Swallow the tablet whole with water, do not crush or chew.
Mechanism of Action
Trospium Chloride is an anticholinergic agent that competitively antagonizes muscarinic receptors on the detrusor muscle of the bladder, leading to relaxation of the bladder muscle and inhibition of involuntary contractions. This reduces urinary urgency and frequency.
Pharmacokinetics
Onset
Clinical effects usually observed within 2-3 weeks.
Excretion
Primarily excreted unchanged in urine via tubular secretion.
Half life
Approximately 18 hours (for 20 mg immediate-release).
Absorption
Approximately 10-15% absorbed orally. Food may reduce absorption.
Metabolism
Minimally metabolized; some hydroxylation and ester hydrolysis.
Side Effects
Contraindications
- Urinary retention
- Gastric retention
- Uncontrolled narrow-angle glaucoma
- Known hypersensitivity to trospium chloride or any component of the product
- Severe hepatic impairment
Drug Interactions
Digoxin
May increase digoxin serum concentrations due to competition for renal tubular secretion.
Anticholinergic agents
Additive anticholinergic effects, potentially increasing risk of dry mouth, constipation, etc.
Drugs eliminated by active tubular secretion (e.g., procainamide, vancomycin, morphine, metformin)
May increase serum levels of these drugs or trospium due to competitive inhibition of active tubular secretion.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms of overdose include severe anticholinergic effects (e.g., severe dry mouth, blurred vision, fast heartbeat, flushed skin, difficulty urinating, constipation, confusion, hallucinations). Treatment is supportive, including gastric lavage and physostigmine if severe anticholinergic symptoms are present.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. It is unknown if trospium is excreted in human milk; caution is advised when administering to a nursing mother.
Side Effects
Contraindications
- Urinary retention
- Gastric retention
- Uncontrolled narrow-angle glaucoma
- Known hypersensitivity to trospium chloride or any component of the product
- Severe hepatic impairment
Drug Interactions
Digoxin
May increase digoxin serum concentrations due to competition for renal tubular secretion.
Anticholinergic agents
Additive anticholinergic effects, potentially increasing risk of dry mouth, constipation, etc.
Drugs eliminated by active tubular secretion (e.g., procainamide, vancomycin, morphine, metformin)
May increase serum levels of these drugs or trospium due to competitive inhibition of active tubular secretion.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms of overdose include severe anticholinergic effects (e.g., severe dry mouth, blurred vision, fast heartbeat, flushed skin, difficulty urinating, constipation, confusion, hallucinations). Treatment is supportive, including gastric lavage and physostigmine if severe anticholinergic symptoms are present.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. It is unknown if trospium is excreted in human milk; caution is advised when administering to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals
Approval Status
Approved by FDA
Patent Status
Generics available
Clinical Trials
Numerous clinical trials have demonstrated the efficacy and safety of trospium chloride in treating OAB symptoms, including reduction in urge incontinence episodes, micturition frequency, and increased voided volume.
Lab Monitoring
- No specific routine lab monitoring is required. Monitor renal function in patients with known impairment.
Doctor Notes
- Advise patients to take trospium on an empty stomach for optimal absorption.
- Monitor elderly patients for anticholinergic side effects and cognitive changes.
- Adjust dose in patients with moderate to severe renal impairment.
Patient Guidelines
- Take medicine exactly as prescribed.
- Do not stop taking the medicine without consulting your doctor.
- Inform your doctor about all other medications you are taking.
- Avoid activities requiring mental alertness until you know how the medicine affects you (e.g., driving).
- Stay hydrated to help manage dry mouth.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause blurred vision, dizziness, or drowsiness. Patients should be cautioned about engaging in activities requiring mental alertness, such as driving or operating machinery, until they know how trospium affects them.
Lifestyle Advice
- Maintain a balanced diet and regular exercise.
- Limit caffeine and alcohol intake.
- Practice timed voiding to help manage OAB symptoms.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.