Trugain-2
Generic Name
Minoxidil Topical Solution
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| trugain 2 scalp solution | ৳ 450.00 | N/A |
Description
Overview of the medicine
Trugain-2 Scalp Solution contains Minoxidil 2% and is used to stimulate hair growth in individuals with androgenetic alopecia (male pattern baldness and female pattern hair loss). It helps to reverse the miniaturization of hair follicles, increase their size, and extend the hair's growth phase.
Uses & Indications
Dosage
Adults
Apply 1 ml of Trugain-2 Scalp Solution twice daily to the affected areas of the scalp. The total dose should not exceed 2 ml per day. Use for a minimum of 4 months for visible results.
Elderly
No specific dosage adjustments are recommended for elderly patients.
Renal_impairment
No specific dosage adjustments are recommended for topical application.
How to Take
Ensure scalp and hair are completely dry. Apply 1 ml (about 10 sprays) to the affected areas of the scalp. Gently massage the solution into the scalp. Wash hands thoroughly after application. Do not wash hair for at least 4 hours after application.
Mechanism of Action
Minoxidil is a potassium channel opener that causes hyperpolarization of cell membranes. Its exact mechanism for hair growth is not fully understood, but it is believed to widen blood vessels, which improves blood flow to hair follicles, and may also stimulate hair follicle cells directly, prolonging the anagen (growth) phase of hair and leading to thicker, longer hair.
Pharmacokinetics
Onset
Hair growth stimulation usually requires 4 months of twice-daily application for visible results.
Excretion
Primarily excreted in urine.
Half life
Systemically absorbed minoxidil has a half-life of approximately 18-28 hours.
Absorption
Approximately 1.4% of the topically applied dose is absorbed systemically. Systemic absorption can be increased by increased dose, frequency of administration, or damaged skin barrier.
Metabolism
Systemically absorbed minoxidil is primarily metabolized by conjugation with glucuronic acid.
Side Effects
Contraindications
- Hypersensitivity to minoxidil or any other ingredients
- Scalp conditions such as sunburn, infection, irritation, or pain
- Concomitant use with other topical scalp medications
- Children under 18 years of age
- Sudden/patchy hair loss or hair loss of unknown reason
Drug Interactions
Guanethidine
Risk of orthostatic hypotension may be increased.
Other topical agents
Avoid concomitant use with other topical medications (e.g., corticosteroids, retinoids, petrolatum) as they may alter minoxidil absorption.
Storage
Store below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Accidental ingestion or application to a large surface area of the scalp could lead to systemic effects of minoxidil, such as hypotension, tachycardia, fluid retention, and dizziness. In such cases, seek immediate medical attention. Treatment is supportive.
Pregnancy & Lactation
Minoxidil is not recommended for use during pregnancy or while breastfeeding due to potential systemic absorption and unknown effects on the fetus/infant. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to minoxidil or any other ingredients
- Scalp conditions such as sunburn, infection, irritation, or pain
- Concomitant use with other topical scalp medications
- Children under 18 years of age
- Sudden/patchy hair loss or hair loss of unknown reason
Drug Interactions
Guanethidine
Risk of orthostatic hypotension may be increased.
Other topical agents
Avoid concomitant use with other topical medications (e.g., corticosteroids, retinoids, petrolatum) as they may alter minoxidil absorption.
Storage
Store below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Accidental ingestion or application to a large surface area of the scalp could lead to systemic effects of minoxidil, such as hypotension, tachycardia, fluid retention, and dizziness. In such cases, seek immediate medical attention. Treatment is supportive.
Pregnancy & Lactation
Minoxidil is not recommended for use during pregnancy or while breastfeeding due to potential systemic absorption and unknown effects on the fetus/infant. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months, check product label for exact date.
Availability
Pharmacies, Drugstores
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of topical minoxidil 2% and 5% in promoting hair growth and slowing hair loss in individuals with androgenetic alopecia.
Lab Monitoring
- No routine lab monitoring required for topical minoxidil use. Monitor for systemic side effects if overdose or excessive absorption is suspected.
Doctor Notes
- Emphasize patient compliance for at least 4-6 months before assessing efficacy.
- Inform patients about initial temporary shedding.
- Advise against exceeding recommended dosage to avoid increased systemic absorption and side effects.
- Counsel on realistic expectations regarding hair regrowth.
Patient Guidelines
- Apply only to a completely dry scalp.
- Use consistently twice daily for best results.
- Wash hands thoroughly after application.
- Do not apply to inflamed or damaged scalp.
- Avoid contact with eyes and other sensitive areas.
- Be patient, results may take 4-6 months to appear.
Missed Dose Advice
If a dose is missed, do not double the next dose. Continue with the regular dosing schedule. Consistent application is key for efficacy.
Driving Precautions
Topical minoxidil is unlikely to affect the ability to drive or operate machinery, as systemic absorption is minimal. However, if dizziness or other systemic side effects occur, avoid such activities.
Lifestyle Advice
- Maintain a healthy diet and lifestyle.
- Manage stress, as stress can contribute to hair loss.
- Avoid harsh hair treatments or tight hairstyles.
- Use mild shampoos and conditioners.
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Global Brand Names
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