Tucatin
Generic Name
Tucatinib
Manufacturer
Hypothetical Pharma Co.
Country
USA
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tucatin 150 mg tablet | ৳ 1,600.00 | ৳ 6,400.00 |
Description
Overview of the medicine
Tucatin 150 mg Tablet contains Tucatinib, a kinase inhibitor indicated for the treatment of advanced unresectable or metastatic HER2-positive breast cancer.
Uses & Indications
Dosage
Adults
300 mg orally twice daily (e.g., two 150 mg tablets) in combination with other agents.
Elderly
No specific dose adjustment required based on age.
Renal_impairment
No dose adjustment required for mild to moderate renal impairment; data limited for severe.
How to Take
Swallow tablets whole with or without food. Do not chew, crush, or split.
Mechanism of Action
Tucatinib is a highly selective tyrosine kinase inhibitor that specifically targets HER2, inhibiting HER2 phosphorylation and HER2-mediated downstream signaling, leading to inhibition of cancer cell growth.
Pharmacokinetics
Onset
Not immediately observable; therapeutic effects seen over weeks.
Excretion
Mainly fecal (84%), with minor renal excretion (1.1%).
Half life
Approximately 8-9 hours.
Absorption
Rapidly absorbed; peak plasma concentration (Tmax) 2 hours.
Metabolism
Primarily metabolized by CYP2C8 and CYP3A4.
Side Effects
Contraindications
- Severe hypersensitivity to Tucatinib or any excipients
- Severe hepatic impairment (consider dose reduction)
Drug Interactions
UGT1A1 substrates (e.g., Irinotecan)
Monitor for increased toxicity.
CYP2C8 inhibitors (e.g., Gemfibrozil)
Avoid co-administration; may increase Tucatinib levels.
Strong CYP3A inducers (e.g., Rifampin)
Avoid co-administration; may decrease Tucatinib levels.
Strong CYP3A inhibitors (e.g., Ketoconazole)
Avoid co-administration; may increase Tucatinib levels.
Storage
Store at room temperature (20°C to 25°C), away from moisture and light. Keep out of reach of children.
Overdose
No specific antidote. Manage overdose symptomatically and provide supportive care. Monitor for adverse reactions.
Pregnancy & Lactation
Not recommended during pregnancy due to potential fetal harm. Avoid breastfeeding during treatment and for 1 week after the last dose.
Side Effects
Contraindications
- Severe hypersensitivity to Tucatinib or any excipients
- Severe hepatic impairment (consider dose reduction)
Drug Interactions
UGT1A1 substrates (e.g., Irinotecan)
Monitor for increased toxicity.
CYP2C8 inhibitors (e.g., Gemfibrozil)
Avoid co-administration; may increase Tucatinib levels.
Strong CYP3A inducers (e.g., Rifampin)
Avoid co-administration; may decrease Tucatinib levels.
Strong CYP3A inhibitors (e.g., Ketoconazole)
Avoid co-administration; may increase Tucatinib levels.
Storage
Store at room temperature (20°C to 25°C), away from moisture and light. Keep out of reach of children.
Overdose
No specific antidote. Manage overdose symptomatically and provide supportive care. Monitor for adverse reactions.
Pregnancy & Lactation
Not recommended during pregnancy due to potential fetal harm. Avoid breastfeeding during treatment and for 1 week after the last dose.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies and hospitals globally
Approval Status
Approved by FDA and EMA
Patent Status
Under patent protection
Clinical Trials
Approved based on results from the HER2CLIMB study, demonstrating improved progression-free and overall survival in patients with HER2-positive metastatic breast cancer.
Lab Monitoring
- Liver function tests (ALT, AST, bilirubin) prior to initiation and every 3 weeks during treatment.
- CBC with differential.
- Serum creatinine and electrolytes.
Doctor Notes
- Monitor LFTs regularly, especially during the first cycle.
- Advise patients on proactive management of diarrhea and PPE.
- Consider dose reduction for severe adverse reactions or moderate hepatic impairment.
Patient Guidelines
- Take Tucatin 150 mg tablet exactly as prescribed by your doctor.
- Inform your doctor about all medications, supplements, and herbal products you are taking.
- Report any severe diarrhea, nausea, vomiting, or signs of liver problems immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose.
Driving Precautions
May cause fatigue or dizziness. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain good hydration.
- Avoid grapefruit and grapefruit juice.
- Practice good skin care, especially for hands and feet, to manage PPE.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.