Tygacil
Generic Name
Tigecycline 50 mg injection
Manufacturer
Pfizer
Country
United States
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tygacil 50 mg injection | ৳ 5,820.00 | N/A |
Description
Overview of the medicine
Tygacil (Tigecycline) is an intravenous antibiotic used to treat serious bacterial infections, including complicated skin and skin structure infections (cSSSI), complicated intra-abdominal infections (cIAI), and community-acquired bacterial pneumonia (CABP). It belongs to the glycylcycline class of antibiotics.
Uses & Indications
Dosage
Adults
Initial dose of 100 mg, followed by 50 mg every 12 hours for 5 to 14 days.
Elderly
No dosage adjustment required based on age.
Renal_impairment
No dosage adjustment required.
How to Take
Administered intravenously (IV) over 30 to 60 minutes.
Mechanism of Action
Tigecycline inhibits protein synthesis in bacteria by binding to the 30S ribosomal subunit, thereby preventing the entry of aminoacyl-tRNA into the A-site of the ribosome. This action is primarily bacteriostatic.
Pharmacokinetics
Onset
Rapid, within minutes of infusion.
Excretion
Primarily excreted unchanged via bile/feces (59%), with a smaller portion via urine (33%).
Half life
Approximately 42 hours (terminal half-life).
Absorption
Administered intravenously, thus 100% bioavailability.
Metabolism
Not extensively metabolized. Glucuronidation is the primary metabolic pathway.
Side Effects
Contraindications
- •Known hypersensitivity to tigecycline or any tetracycline antibiotics
- •Children under 8 years of age (due to potential for permanent tooth discoloration)
Drug Interactions
Warfarin
Tigecycline may prolong prothrombin time (INR).
Oral Contraceptives
May reduce efficacy of oral contraceptives.
Storage
Store unopened vials at 20-25°C (68-77°F), excursions permitted to 15-30°C (59-86°F). Reconstituted solution should be used immediately.
Overdose
No specific antidote. Management involves symptomatic and supportive care. Tigecycline is not significantly removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category D. May cause permanent tooth discoloration and inhibit bone growth in the fetus. Not recommended during breastfeeding due to potential harm to the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, refer to packaging for exact date.
Availability
Hospitals, Pharmacies
Approval Status
FDA approved
Patent Status
Patent expired
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Global Brand Names
International brand names for this medicine
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