Tylen
Generic Name
Paracetamol (Acetaminophen)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tylen 120 mg suspension | ৳ 35.00 | N/A |
Description
Overview of the medicine
Tylen 120 mg Suspension is used for the symptomatic treatment of mild to moderate pain and fever in children.
Uses & Indications
Dosage
Adults
Not typically used for adults in this specific concentration; adult formulations are available.
Elderly
Not typically used for elderly in this specific concentration; adult formulations are available.
Renal_impairment
Use with caution in renal impairment. For severe impairment (creatinine clearance < 10 ml/min), the dosing interval should be extended to 8 hours.
How to Take
Administer orally, with or without food. Use a measuring spoon or oral syringe for accurate dosing.
Mechanism of Action
Paracetamol is thought to act primarily in the central nervous system, inhibiting prostaglandin synthesis, which reduces pain and fever.
Pharmacokinetics
Onset
Analgesic effect within 30-60 minutes, antipyretic effect within 30 minutes.
Excretion
Excreted mainly in the urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
Plasma half-life is 1 to 4 hours.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract; peak plasma concentration typically within 30-60 minutes.
Metabolism
Mainly metabolized in the liver (hepatic) by conjugation with glucuronic acid, sulfuric acid, and cysteine. A small amount is metabolized by cytochrome P450 enzymes to a toxic intermediate, N-acetyl-p-benzoquinone imine (NAPQI), which is normally detoxified by glutathione.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation
- Severe hepatic impairment or active liver disease
Drug Interactions
Alcohol
Chronic alcohol use increases the risk of hepatotoxicity with paracetamol.
Warfarin
May enhance the anticoagulant effect of warfarin, increasing the risk of bleeding.
Other Paracetamol-containing products
Increased risk of overdose and hepatotoxicity.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep the bottle tightly closed.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, pallor, and sweating. Severe overdose can lead to hepatic necrosis. Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (antidote).
Pregnancy & Lactation
Paracetamol is generally considered safe for use during pregnancy and lactation at recommended therapeutic doses. However, always consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation
- Severe hepatic impairment or active liver disease
Drug Interactions
Alcohol
Chronic alcohol use increases the risk of hepatotoxicity with paracetamol.
Warfarin
May enhance the anticoagulant effect of warfarin, increasing the risk of bleeding.
Other Paracetamol-containing products
Increased risk of overdose and hepatotoxicity.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep the bottle tightly closed.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, pallor, and sweating. Severe overdose can lead to hepatic necrosis. Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (antidote).
Pregnancy & Lactation
Paracetamol is generally considered safe for use during pregnancy and lactation at recommended therapeutic doses. However, always consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 2 to 3 years from the manufacturing date when stored correctly.
Availability
Pharmacies, drugstores, supermarkets
Approval Status
Approved (Over-The-Counter)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Paracetamol has been extensively studied for decades, confirming its efficacy and safety profile in various populations, including pediatric. Ongoing research continues to explore its specific mechanisms and interactions.
Lab Monitoring
- Liver function tests (ALT, AST) in cases of suspected overdose or prolonged high-dose therapy.
- Serum paracetamol levels in overdose cases.
Doctor Notes
- Emphasize accurate dose calculation based on patient's weight or age (e.g., 10-15 mg/kg per dose).
- Educate parents/caregivers about the risks of exceeding the maximum daily dose and concomitant use with other paracetamol-containing products.
- Counsel on recognizing signs of hepatotoxicity and seeking immediate medical attention in case of suspected overdose.
Patient Guidelines
- Always use the provided measuring device to ensure accurate dosing.
- Do not exceed the recommended dose or frequency.
- Do not use with other paracetamol-containing products.
- Consult a doctor if fever persists for more than 3 days or pain for more than 5 days.
- Keep out of reach of children.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Paracetamol is not known to impair the ability to drive or operate machinery.
Lifestyle Advice
- Ensure adequate hydration, especially when managing fever.
- Maintain a balanced diet.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.