Typhim Vi
Generic Name
Typhoid Polysaccharide Vaccine
Manufacturer
Sanofi Pasteur
Country
France
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| typhim vi 25 mcg injection | ৳ 910.00 | N/A |
Description
Overview of the medicine
Typhim Vi is a vaccine used to prevent typhoid fever caused by the bacterium *Salmonella typhi*. It contains purified Vi capsular polysaccharide antigen from *Salmonella typhi* which stimulates the immune system to produce protective antibodies.
Uses & Indications
Dosage
Adults
A single 0.5 mL (25 mcg) dose administered by intramuscular injection. A booster dose is recommended every 3 years for continued protection.
Elderly
No specific dose adjustment is required; the standard 0.5 mL dose is administered.
Renal_impairment
No specific dose adjustment is considered necessary for patients with renal impairment.
How to Take
Typhim Vi should be administered by intramuscular injection, preferably into the deltoid muscle in adults and children. Do not inject intravenously. Shake well before use.
Mechanism of Action
This vaccine works by stimulating the immune system to produce specific antibodies against the Vi capsular polysaccharide antigen of *Salmonella typhi*. These antibodies provide protection against subsequent exposure to the bacterium, thereby preventing typhoid fever.
Pharmacokinetics
Onset
Protective immunity typically develops within 7-14 days after a single dose.
Excretion
Not applicable; the vaccine's role is immune stimulation, not systemic elimination of an active drug.
Half life
Not applicable in the conventional pharmacokinetic sense for vaccine antigens. The generated antibodies have their own half-life, and protection lasts about 3 years.
Absorption
Administered intramuscularly, the Vi polysaccharide antigen is absorbed and processed by antigen-presenting cells to elicit an immune response.
Metabolism
The antigen is processed and degraded by the immune system cells.
Side Effects
Contraindications
- Hypersensitivity to the active substance or any of the excipients of the vaccine.
- Acute febrile illness or acute infection: Vaccination should be postponed until recovery.
Drug Interactions
Other Vaccines
Typhim Vi can be administered concurrently with other routine vaccines (e.g., Yellow Fever, Hepatitis A) using separate injection sites and syringes.
Immunosuppressive Therapy
May reduce the immune response to the vaccine. Consider deferring vaccination until immune status improves, if possible.
Storage
Store in a refrigerator (2°C to 8°C). Do not freeze. Protect from light. Keep out of reach of children.
Overdose
Not applicable for a vaccine. Overdose is unlikely to occur and would not lead to specific adverse effects beyond those associated with a standard dose.
Pregnancy & Lactation
Pregnancy: Use in pregnancy should only be considered if clearly needed and the potential benefits outweigh the risks. Animal reproduction studies are not always predictive of human response. Lactation: It is not known whether this vaccine is excreted in human milk. Caution should be exercised when administering to a nursing mother, though it is generally considered safe.
Side Effects
Contraindications
- Hypersensitivity to the active substance or any of the excipients of the vaccine.
- Acute febrile illness or acute infection: Vaccination should be postponed until recovery.
Drug Interactions
Other Vaccines
Typhim Vi can be administered concurrently with other routine vaccines (e.g., Yellow Fever, Hepatitis A) using separate injection sites and syringes.
Immunosuppressive Therapy
May reduce the immune response to the vaccine. Consider deferring vaccination until immune status improves, if possible.
Storage
Store in a refrigerator (2°C to 8°C). Do not freeze. Protect from light. Keep out of reach of children.
Overdose
Not applicable for a vaccine. Overdose is unlikely to occur and would not lead to specific adverse effects beyond those associated with a standard dose.
Pregnancy & Lactation
Pregnancy: Use in pregnancy should only be considered if clearly needed and the potential benefits outweigh the risks. Animal reproduction studies are not always predictive of human response. Lactation: It is not known whether this vaccine is excreted in human milk. Caution should be exercised when administering to a nursing mother, though it is generally considered safe.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture when stored correctly.
Availability
Pharmacies, hospitals, clinics, travel clinics
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Typhim Vi in preventing typhoid fever, with protection rates ranging from 70% to 90% in various populations.
Lab Monitoring
- No routine laboratory monitoring is required. Antibody titres can be measured to confirm seroconversion, but this is not typically done for clinical management.
Doctor Notes
- Ensure proper cold chain storage is maintained for the vaccine.
- Verify the patient's age (must be 2 years or older) before administration.
- Administer intramuscularly; avoid intravascular injection.
- Advise patients about the importance of booster doses every 3 years for ongoing protection.
Patient Guidelines
- Inform your healthcare provider about any allergies or previous vaccine reactions.
- Report any severe or persistent reactions after vaccination.
- Continue practicing good food and water hygiene, as the vaccine does not offer 100% protection.
- A booster dose is recommended every 3 years for continuous protection.
Missed Dose Advice
Since Typhim Vi is typically a single initial dose followed by boosters, if a booster dose is missed, it should be administered as soon as feasible to maintain protection.
Driving Precautions
Typhim Vi is not expected to affect the ability to drive or operate machinery. However, if you experience headache or malaise, it is advisable to wait until symptoms resolve before driving or operating machinery.
Lifestyle Advice
- Even after vaccination, it is crucial to maintain strict food and water safety practices, especially when traveling to or residing in areas where typhoid fever is endemic. Wash hands frequently, consume only bottled or boiled water, and eat well-cooked food.
- Avoid raw or undercooked foods and unpeeled fruits and vegetables.
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