Tysul
Generic Name
Sulpiride
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tysul 50 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Tysul 50 mg Tablet contains Sulpiride, an atypical antipsychotic primarily used to treat schizophrenia, vertigo, and certain gastrointestinal disorders like irritable bowel syndrome and dyspepsia.
Uses & Indications
Dosage
Adults
For vertigo/GI disorders: 50 mg 2-3 times daily. For psychosis: 200-400 mg twice daily, up to 1600 mg daily in divided doses. Dosage should be individualized.
Elderly
Lower starting doses (e.g., 50-100 mg daily), with gradual titration. Monitor closely for side effects due to increased sensitivity.
Renal_impairment
Dose reduction required. For CrCl <60 mL/min, halve the dose. For CrCl <30 mL/min, use 1/4th of the usual dose. Not recommended for severe impairment.
How to Take
Tysul tablets are for oral administration. They can be taken with or without food. To avoid potential sleep disturbances, it is advisable not to take the last dose late in the evening.
Mechanism of Action
Sulpiride acts as a selective antagonist of dopamine D2 receptors in the limbic system, leading to its antipsychotic, antiemetic, and anxiolytic effects. At lower doses, it can block presynaptic D2 receptors, enhancing dopaminergic transmission.
Pharmacokinetics
Onset
Clinical effects may take days to weeks for psychiatric conditions; antiemetic effects may be quicker.
Excretion
Mainly excreted unchanged in urine and feces.
Half life
Elimination half-life is approximately 7-9 hours, prolonged in renal impairment.
Absorption
Oral absorption is moderate (25-35%), reaching peak plasma concentrations in 3-6 hours. Food may slightly reduce absorption.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to Sulpiride or excipients
- Phaeochromocytoma
- Prolactin-dependent tumors (e.g., breast cancer, pituitary adenoma)
- Acute porphyria
- Concomitant use with levodopa
Drug Interactions
Levodopa
Antagonistic effect, contraindicated due to reciprocal antagonism.
Antacids and Sucralfate
May reduce the absorption of Sulpiride; administer at least 2 hours apart.
Alcohol and CNS depressants
Increased sedative effect.
Hypokalaemic agents (e.g., diuretics)
Increase the risk of QT prolongation; correct potassium levels.
Drugs prolonging QT interval (e.g., antiarrhythmics, tricyclic antidepressants)
Increased risk of ventricular arrhythmias, including Torsade de Pointes.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, sedation, blurred vision, dry mouth, tachycardia, hypotension, extrapyramidal symptoms, and possibly coma. Treatment is symptomatic and supportive, including monitoring vital signs and ECG.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Sulpiride is excreted in breast milk; therefore, breastfeeding is not recommended during treatment.
Side Effects
Contraindications
- Known hypersensitivity to Sulpiride or excipients
- Phaeochromocytoma
- Prolactin-dependent tumors (e.g., breast cancer, pituitary adenoma)
- Acute porphyria
- Concomitant use with levodopa
Drug Interactions
Levodopa
Antagonistic effect, contraindicated due to reciprocal antagonism.
Antacids and Sucralfate
May reduce the absorption of Sulpiride; administer at least 2 hours apart.
Alcohol and CNS depressants
Increased sedative effect.
Hypokalaemic agents (e.g., diuretics)
Increase the risk of QT prolongation; correct potassium levels.
Drugs prolonging QT interval (e.g., antiarrhythmics, tricyclic antidepressants)
Increased risk of ventricular arrhythmias, including Torsade de Pointes.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, sedation, blurred vision, dry mouth, tachycardia, hypotension, extrapyramidal symptoms, and possibly coma. Treatment is symptomatic and supportive, including monitoring vital signs and ECG.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Sulpiride is excreted in breast milk; therefore, breastfeeding is not recommended during treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the manufacturing date. Check the expiry date on the packaging.
Availability
Pharmacies, hospitals
Approval Status
Approved in many countries
Patent Status
Off-patent
Clinical Trials
Sulpiride has been extensively studied since its introduction. Ongoing research explores its efficacy in various neuropsychiatric conditions, including treatment-resistant depression and specific anxiety disorders.
Lab Monitoring
- Serum prolactin levels (especially if symptoms like galactorrhea or amenorrhea occur)
- ECG (before and during treatment, particularly in patients with cardiac risk factors)
- Blood pressure monitoring
- Renal function tests (e.g., creatinine clearance)
Doctor Notes
- Monitor for extrapyramidal symptoms, prolactin levels, and ECG changes, especially in high-risk patients.
- Use with caution in elderly patients and those with a history of seizures or cardiovascular disease.
- Educate patients on potential side effects and the importance of adherence.
Patient Guidelines
- Do not stop taking Tysul abruptly without consulting your doctor, as this can lead to withdrawal symptoms.
- Report any unusual or uncontrolled movements of the face, tongue, or limbs to your doctor.
- Avoid alcohol consumption while taking this medication.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Tysul may cause drowsiness, dizziness, or blurred vision. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that Sulpiride therapy does not affect them adversely.
Lifestyle Advice
- Maintain a healthy diet and engage in regular physical activity to manage potential weight gain.
- Ensure adequate hydration.
- Avoid smoking as it can affect drug metabolism.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.