U4
Generic Name
u4-05-mg-tablet
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| u4 05 mg tablet | ৳ 5.01 | ৳ 50.10 |
Description
Overview of the medicine
U4-05-mg-tablet is an antihistamine medication used to relieve symptoms of allergic conditions such as hay fever, allergic rhinitis, and chronic urticaria. It helps to reduce itching, sneezing, and runny nose.
Uses & Indications
Dosage
Adults
Adults and adolescents (12 years and above): 0.5 mg once daily, preferably in the evening.
Elderly
Elderly patients with normal renal function may follow adult dosage. Dose adjustment needed for renal impairment.
Renal_impairment
Moderate renal impairment (CrCl 30-49 mL/min): 0.5 mg every other day. Severe renal impairment (CrCl <30 mL/min): Contraindicated.
How to Take
Take the tablet orally with or without food. Do not crush or chew the tablet; swallow it whole with water.
Mechanism of Action
U4-05-mg-tablet works by selectively blocking H1 histamine receptors, thereby preventing histamine from binding to these receptors. This action reduces the allergic response mediated by histamine, such as vasodilation, increased capillary permeability, and smooth muscle contraction, leading to relief from allergic symptoms.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Mainly excreted via the kidneys in urine, both as unchanged drug and inactive metabolites.
Half life
Approximately 8-10 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations reached within 1-2 hours.
Metabolism
Minimal hepatic metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to the active ingredient or any component of the tablet.
- End-stage renal disease (CrCl < 10 mL/min) or patients undergoing hemodialysis.
- Severe hepatic impairment.
Drug Interactions
Ritonavir
May increase plasma concentrations of U4-05-mg-tablet. Close monitoring for adverse effects is recommended.
Central Nervous System Depressants (e.g., alcohol, sedatives)
May increase the risk of drowsiness and CNS depression. Concurrent use should be avoided or monitored carefully.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, somnolence, and in children, agitation. Treatment should be symptomatic and supportive. Gastric lavage and activated charcoal may be considered if taken recently.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. It is excreted in human milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to the active ingredient or any component of the tablet.
- End-stage renal disease (CrCl < 10 mL/min) or patients undergoing hemodialysis.
- Severe hepatic impairment.
Drug Interactions
Ritonavir
May increase plasma concentrations of U4-05-mg-tablet. Close monitoring for adverse effects is recommended.
Central Nervous System Depressants (e.g., alcohol, sedatives)
May increase the risk of drowsiness and CNS depression. Concurrent use should be avoided or monitored carefully.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, somnolence, and in children, agitation. Treatment should be symptomatic and supportive. Gastric lavage and activated charcoal may be considered if taken recently.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. It is excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved for general use
Patent Status
Patent expired
Clinical Trials
Clinical trials have demonstrated the efficacy and safety of U4-05-mg-tablet in reducing allergic symptoms with a favorable tolerability profile.
Lab Monitoring
- No routine lab monitoring is generally required for U4-05-mg-tablet.
Doctor Notes
- Advise patients about potential drowsiness, especially when starting treatment.
- Assess renal function in elderly patients and those with known kidney impairment before prescribing and during treatment.
- Counsel patients to report any unusual or severe side effects.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid alcohol while taking this medication as it may increase drowsiness.
- Inform your doctor or pharmacist about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause drowsiness or dizziness. Do not drive or operate machinery if you experience these effects.
Lifestyle Advice
- Avoid activities requiring mental alertness, such as driving or operating heavy machinery, until you know how this medicine affects you.
- Maintain adequate hydration.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.