Udiliva
Generic Name
Ursodeoxycholic Acid
Manufacturer
Sun Pharmaceutical Industries Ltd.
Country
India
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| udiliva 150 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Udiliva 150 mg Tablet contains Ursodeoxycholic Acid, a naturally occurring bile acid. It is primarily used to dissolve certain types of gallstones and treat primary biliary cholangitis (PBC), a chronic liver disease.
Uses & Indications
Dosage
Adults
For gallstone dissolution: 8-10 mg/kg/day, usually divided into 2-3 doses. For PBC: 13-15 mg/kg/day, divided into 2-4 doses.
Elderly
No specific dose adjustment required, but monitor liver function regularly.
Renal_impairment
No specific dose adjustment required for renal impairment, but caution is advised in severe renal disease.
How to Take
Udiliva tablets should be taken orally, usually with food to improve absorption and reduce gastrointestinal upset. Take as directed by a physician, often at bedtime or divided throughout the day.
Mechanism of Action
Ursodeoxycholic Acid increases the solubility of cholesterol in bile, leading to the dissolution of cholesterol gallstones. In primary biliary cholangitis (PBC), it reduces the accumulation of toxic bile acids in the liver, protecting liver cells and slowing disease progression.
Pharmacokinetics
Onset
Gallstone dissolution may take 6 months to 2 years. Clinical improvement in PBC may be observed within a few weeks to months.
Excretion
Primarily excreted in bile and feces (via enterohepatic recirculation), with a very small amount appearing in urine.
Half life
Approximately 3.5 to 5.8 days.
Absorption
Well absorbed from the gastrointestinal tract (about 90%). Peak plasma concentrations are reached in 1-3 hours.
Metabolism
Extensively metabolized in the liver to various conjugated forms, primarily with glycine and taurine, and further oxidized by gut bacteria.
Side Effects
Contraindications
- Acute inflammation of the gallbladder or bile ducts.
- Occlusion of the biliary tract (e.g., common bile duct obstruction).
- Calcified gallstones.
- Non-functioning gallbladder.
- Frequent episodes of biliary colic.
- Allergy to ursodeoxycholic acid or any component of the formulation.
Drug Interactions
Ciclosporin
UDCA may increase the absorption of ciclosporin. Monitor ciclosporin levels and adjust dose if necessary.
Cholestyramine, Colestipol
These bile acid sequestrants can bind UDCA and reduce its absorption. Administer at least 2 hours apart.
Antacids containing aluminum
Can reduce the absorption of UDCA. Administer antacids at least 2 hours apart from UDCA.
Oral contraceptives, Estrogens, Clofibrate
May increase cholesterol saturation of bile, potentially counteracting the effect of UDCA.
Storage
Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.
Overdose
The most common symptom of overdose is diarrhea. Treatment is symptomatic and supportive. No specific antidote is known.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed and the potential benefits outweigh the risks. Excreted into breast milk in very small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture, specific details on packaging.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available
Clinical Trials
Ursodeoxycholic Acid has been extensively studied in numerous clinical trials for its efficacy in gallstone dissolution and treatment of primary biliary cholangitis, showing significant benefits and a favorable safety profile.
Lab Monitoring
- Liver function tests (ALT, AST, ALP, bilirubin) should be monitored initially and periodically (e.g., every 1-3 months) during treatment, especially for PBC patients.
- Gallbladder ultrasound periodically (e.g., every 6-12 months) for gallstone dissolution to monitor treatment efficacy.
Doctor Notes
- Emphasize the importance of patient compliance for the efficacy of gallstone dissolution, which requires prolonged therapy.
- Regular monitoring of liver function tests is crucial, especially in PBC patients, to assess response and potential adverse effects.
- Advise patients about potential drug interactions, particularly with aluminum-containing antacids and bile acid sequestrants.
Patient Guidelines
- Take Udiliva with food as directed by your doctor.
- Do not stop treatment without consulting your doctor, even if you feel better.
- Report any severe or persistent diarrhea, abdominal pain, or jaundice to your doctor immediately.
- If you are using this medicine for gallstones, you may need to continue treatment for an extended period.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Generally, Udiliva does not impair the ability to drive or operate machinery. However, if you experience dizziness, it is advisable to avoid such activities.
Lifestyle Advice
- Maintain a balanced, low-cholesterol diet, especially if treating gallstones.
- Avoid excessive alcohol consumption, as it can worsen liver conditions.
- Stay hydrated by drinking plenty of water.
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