Ufol
Generic Name
Propofol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ufol 200 mg emulsion for infusion | ৳ 300.00 | N/A |
Description
Overview of the medicine
Propofol is a short-acting intravenous general anesthetic agent used for the induction and maintenance of general anesthesia, sedation of mechanically ventilated adults, and for monitored anesthesia care.
Uses & Indications
Dosage
Adults
For induction of general anesthesia: 2-2.5 mg/kg IV. For maintenance: 4-12 mg/kg/hr IV. For ICU sedation: 0.3-4 mg/kg/hr IV.
Elderly
Reduced dosage is usually required; for induction, typically 1-1.5 mg/kg IV. Close monitoring is essential.
Renal_impairment
No specific dose adjustment is generally required, but caution is advised in severe renal impairment.
How to Take
Administered intravenously as an emulsion. Should only be administered by persons trained in the use of general anesthesia and in the management of airways. Requires continuous monitoring of vital signs.
Mechanism of Action
Propofol is believed to exert its anesthetic and sedative effects by potentiating the inhibitory function of the neurotransmitter GABA (gamma-aminobutyric acid) through GABA-A receptors. It slows the dissociation of GABA from the receptor, leading to prolonged opening of chloride channels and hyperpolarization of neurons.
Pharmacokinetics
Onset
30-60 seconds after intravenous administration.
Excretion
Metabolites are primarily excreted via the kidneys.
Half life
Initial distribution half-life of 2-8 minutes, followed by a slower elimination phase with a terminal half-life of 2-4 hours.
Absorption
Administered intravenously, onset of action is rapid (within 30-60 seconds).
Metabolism
Extensively metabolized in the liver, primarily by conjugation to glucuronide and sulfate metabolites, which are inactive. Extrahepatic metabolism also occurs.
Side Effects
Contraindications
- Known hypersensitivity to propofol or any component of the formulation
- Patients allergic to eggs or soy (due to lipid emulsion components)
- Obstetric sedation (except for termination of pregnancy)
Drug Interactions
Volatile Anesthetics
Synergistic effects, requiring lower doses of propofol.
Neuromuscular Blockers
No significant direct interaction, but propofol can reduce the requirement for some muscle relaxants.
Opioids, Sedatives, other CNS depressants
Increased sedative and respiratory depressant effects.
Storage
Store below 25°C. Do not freeze. Protect from light. Discard any unused portion after opening immediately.
Overdose
Overdose can lead to cardiorespiratory depression including apnea, airway obstruction, hypotension, and bradycardia. Treatment involves discontinuing the infusion, maintaining a patent airway, assisting ventilation, and administering vasopressors and fluid expanders for hypotension.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Propofol crosses the placenta. Excreted in breast milk, caution advised.
Side Effects
Contraindications
- Known hypersensitivity to propofol or any component of the formulation
- Patients allergic to eggs or soy (due to lipid emulsion components)
- Obstetric sedation (except for termination of pregnancy)
Drug Interactions
Volatile Anesthetics
Synergistic effects, requiring lower doses of propofol.
Neuromuscular Blockers
No significant direct interaction, but propofol can reduce the requirement for some muscle relaxants.
Opioids, Sedatives, other CNS depressants
Increased sedative and respiratory depressant effects.
Storage
Store below 25°C. Do not freeze. Protect from light. Discard any unused portion after opening immediately.
Overdose
Overdose can lead to cardiorespiratory depression including apnea, airway obstruction, hypotension, and bradycardia. Treatment involves discontinuing the infusion, maintaining a patent airway, assisting ventilation, and administering vasopressors and fluid expanders for hypotension.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Propofol crosses the placenta. Excreted in breast milk, caution advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years when stored as recommended.
Availability
Hospitals, Clinics, Pharmacies (with prescription)
Approval Status
Approved by FDA/DGDA
Patent Status
Patent expired for generic propofol
WHO Essential Medicine
YesClinical Trials
Propofol has been extensively studied in numerous clinical trials establishing its efficacy and safety for general anesthesia and sedation across various patient populations, including pediatric and adult critical care.
Lab Monitoring
- Arterial Blood Pressure
- Heart Rate
- Respiratory Rate
- Oxygen Saturation
- ECG
- Lipid levels (for prolonged ICU sedation)
- Creatine Kinase (CK) levels (if PRIS suspected)
Doctor Notes
- Careful titration is required to achieve desired depth of anesthesia/sedation.
- Monitor for signs of respiratory and cardiovascular depression.
- Ensure adequate resuscitation equipment is immediately available.
Patient Guidelines
- This medication is administered by a healthcare professional.
- Report any discomfort or unusual feelings during or after administration.
- Do not drive or operate machinery for at least 24 hours after receiving propofol.
Missed Dose Advice
Not applicable as propofol is administered by a healthcare professional for specific procedures or continuous sedation under medical supervision.
Driving Precautions
Driving and operating machinery are strictly prohibited for at least 24 hours after propofol administration due to residual sedative effects.
Lifestyle Advice
- Avoid alcohol and other CNS depressants for at least 24 hours after administration.
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