Ultrafen-SR
Generic Name
Diclofenac Sodium Sustained Release 100 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ultrafen sr 100 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Ultrafen-SR 100 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and swelling in various conditions like arthritis, muscle pain, and dental pain. Its sustained-release formulation ensures prolonged action, allowing for once-daily dosing.
Uses & Indications
Dosage
Adults
100 mg once daily, preferably with food. The maximum daily dose is usually 100 mg.
Elderly
Use with caution, lowest effective dose for the shortest duration possible, due to increased risk of adverse effects.
Renal_impairment
Use with caution; dosage adjustment may be required in severe renal impairment (CrCl <30 mL/min). Avoid in end-stage renal disease.
How to Take
Take orally, preferably with or after food. Swallow the tablet whole; do not crush, chew, or break it, as it is a sustained-release formulation.
Mechanism of Action
Inhibits cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of pain and inflammation.
Pharmacokinetics
Onset
Onset of pain relief within 1-2 hours; full anti-inflammatory effects may take several days.
Excretion
Excreted primarily via urine (approximately 60%) as metabolites and bile/feces (approximately 30%).
Half life
Plasma half-life is approximately 1-2 hours for the parent compound, but the therapeutic effect can last longer due to tissue distribution.
Absorption
Well absorbed from the gastrointestinal tract; sustained-release formulation delays peak plasma concentrations. Bioavailability is about 50%.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C9, with significant first-pass metabolism. Forms several hydroxylated metabolites.
Side Effects
Contraindications
- •Hypersensitivity to diclofenac or other NSAIDs
- •Active peptic ulceration or gastrointestinal bleeding
- •Severe hepatic or renal impairment
- •Severe heart failure (NYHA Class II-IV)
- •History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
- •Third trimester of pregnancy
- •Coronary artery bypass graft (CABG) surgery
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding when co-administered with Selective Serotonin Reuptake Inhibitors (SSRIs).
Corticosteroids
Concomitant administration with corticosteroids may increase the risk of gastrointestinal ulceration or bleeding.
Lithium/Methotrexate
May increase plasma concentrations of Lithium and Methotrexate, leading to toxicity. Monitor levels.
Diuretics and ACE Inhibitors
Decreased antihypertensive effect and increased risk of renal impairment, especially in dehydrated patients.
Warfarin and other anticoagulants
Increased risk of bleeding. Close monitoring of INR/PT is recommended.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Less common effects include acute renal failure, respiratory depression, and coma. Management is symptomatic and supportive, including gastric lavage or activated charcoal if ingestion is recent. Monitor vital signs and renal function.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus and potential inhibition of uterine contractions. Use with caution during the first and second trimesters only if clearly needed and the potential benefits outweigh the risks. Diclofenac is excreted in breast milk; advise against use during lactation due to potential adverse effects on the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Patent expired (Generic)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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