UltranaX
Generic Name
Naxoprofen
Manufacturer
MediCare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ultranax 500 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
UltranaX 500 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve mild to moderate pain, inflammation, and fever.
Uses & Indications
Dosage
Adults
The usual adult dose is 500 mg once or twice daily, or as directed by the physician. Doses should not exceed 1000 mg per day.
Elderly
A lower initial dose is recommended for elderly patients, with close monitoring of renal function.
Renal_impairment
Dosage reduction is necessary in patients with moderate to severe renal impairment. Regular monitoring of renal function is advised.
How to Take
For oral administration. To minimize gastrointestinal discomfort, it is best taken with food, milk, or antacids.
Mechanism of Action
Naxoprofen works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins. This reduction in prostaglandin synthesis leads to its analgesic, anti-inflammatory, and antipyretic effects.
Pharmacokinetics
Onset
Analgesic effect typically begins within 30-60 minutes.
Excretion
Excreted mainly in the urine (approximately 95%) as metabolites and conjugates, with a small amount excreted in feces.
Half life
Plasma elimination half-life ranges from 10 to 15 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations achieved within 1-2 hours.
Metabolism
Primarily metabolized in the liver via glucuronidation and other CYP enzyme pathways.
Side Effects
Contraindications
- Known hypersensitivity to Naxoprofen, aspirin, or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
ACE Inhibitors/Diuretics
Reduced antihypertensive and diuretic effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive treatment. Gastric lavage and activated charcoal may be considered within the first hour of ingestion.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to potential fetal harm. Use with caution during the first and second trimesters only if the potential benefit outweighs the risk. Naxoprofen is excreted in breast milk; therefore, caution is advised during lactation.
Side Effects
Contraindications
- Known hypersensitivity to Naxoprofen, aspirin, or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
ACE Inhibitors/Diuretics
Reduced antihypertensive and diuretic effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive treatment. Gastric lavage and activated charcoal may be considered within the first hour of ingestion.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to potential fetal harm. Use with caution during the first and second trimesters only if the potential benefit outweighs the risk. Naxoprofen is excreted in breast milk; therefore, caution is advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available, original patent expired
Clinical Trials
Clinical trials have established the efficacy and safety profile of Naxoprofen for its approved indications, demonstrating significant reduction in pain and inflammation compared to placebo.
Lab Monitoring
- Regular monitoring of renal function (serum creatinine, BUN) with long-term use
- Liver function tests (ALT, AST) periodically
- Complete blood count (CBC) for signs of bleeding or anemia with prolonged therapy
Doctor Notes
- Assess patient's cardiovascular and gastrointestinal risk factors before initiating therapy.
- Use the lowest effective dose for the shortest possible duration consistent with individual patient treatment goals.
- Monitor renal function, liver enzymes, and blood pressure regularly in patients on long-term therapy.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Always take with food or milk to reduce stomach upset.
- Do not exceed the recommended dose.
- Report any unusual bleeding, persistent stomach pain, or dark stools to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
UltranaX may cause dizziness or drowsiness in some individuals. Patients should be cautioned about driving or operating machinery until they are reasonably certain that the medicine does not adversely affect them.
Lifestyle Advice
- Maintain adequate hydration, especially if taking diuretics.
- Avoid excessive alcohol consumption, as it may increase the risk of gastrointestinal side effects.
- Engage in regular, moderate exercise if appropriate for your condition.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.