Umactin-BD
Generic Name
Aceclofenac
Manufacturer
Unimed Unihealth Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| umactin bd 75 mg capsule | ৳ 23.00 | ৳ 230.00 |
Description
Overview of the medicine
Umactin-BD 75 mg Capsule contains Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID) used for the relief of pain and inflammation in various musculoskeletal and joint conditions. The 'BD' in the brand name often implies a twice-daily dosage, which is consistent with sustained-release formulations aimed at prolonged action.
Uses & Indications
Dosage
Adults
The usual adult dose is one Umactin-BD 75 mg capsule twice daily (every 12 hours) after food. Dosage should be individualized based on patient response and tolerability.
Elderly
No specific dose reduction is generally required, but caution should be exercised, and the lowest effective dose should be used due to increased risk of adverse effects.
Renal_impairment
In mild to moderate renal impairment, initiation with a reduced dose and careful monitoring is advised. Not recommended in severe renal impairment.
How to Take
Take the capsule whole with water after food. Do not chew or crush. Taking with food helps to reduce gastrointestinal side effects.
Mechanism of Action
Aceclofenac exerts its anti-inflammatory, analgesic, and antipyretic effects primarily by inhibiting prostaglandin synthesis through the inhibition of cyclooxygenase (COX) enzymes, especially COX-2. It also appears to inhibit the production of inflammatory cytokines and has chondroprotective properties.
Pharmacokinetics
Onset
Within 30-60 minutes for analgesic effect, full anti-inflammatory effect may take several days.
Excretion
Approximately two-thirds of the dose is excreted via urine and one-third via faeces, mainly as hydroxylated metabolites.
Half life
Approximately 4-4.3 hours.
Absorption
Well absorbed orally; peak plasma concentrations achieved in 1-3 hours for immediate release, prolonged for SR formulations. Bioavailability is approximately 100%.
Metabolism
Extensively metabolized in the liver, primarily via cytochrome P450 2C9 to 4'-hydroxyaceclofenac, and other metabolites.
Side Effects
Contraindications
- Hypersensitivity to aceclofenac or any component of the formulation
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulceration
- Severe heart failure
- Severe renal impairment
- Severe hepatic impairment
- Third trimester of pregnancy
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Warfarin/Anticoagulants
Increased risk of bleeding.
Diuretics/ACE Inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, gastrointestinal bleeding, headache, dizziness, drowsiness. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential fetal adverse effects on the cardiovascular system. Use during first and second trimesters only if clearly needed and benefits outweigh risks. Avoid during lactation as aceclofenac is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to aceclofenac or any component of the formulation
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulceration
- Severe heart failure
- Severe renal impairment
- Severe hepatic impairment
- Third trimester of pregnancy
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Warfarin/Anticoagulants
Increased risk of bleeding.
Diuretics/ACE Inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, gastrointestinal bleeding, headache, dizziness, drowsiness. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential fetal adverse effects on the cardiovascular system. Use during first and second trimesters only if clearly needed and benefits outweigh risks. Avoid during lactation as aceclofenac is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved in Bangladesh
Patent Status
Generic available, patent expired for active ingredient
Clinical Trials
Numerous clinical trials have established the efficacy and safety of aceclofenac in various inflammatory and painful conditions, demonstrating comparable efficacy to other NSAIDs with a generally good tolerability profile.
Lab Monitoring
- Complete Blood Count (CBC)
- Liver function tests (LFTs)
- Renal function tests (e.g., serum creatinine, BUN)
Doctor Notes
- Prescribe the lowest effective dose for the shortest possible duration to minimize adverse effects.
- Monitor patients for signs of GI bleeding, cardiovascular events, and renal/hepatic dysfunction, especially during long-term therapy.
- Consider proton pump inhibitors for GI protection in high-risk patients.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Report any unusual bleeding, persistent stomach pain, or dark stools to your doctor immediately.
- Avoid concurrent use of other NSAIDs without medical advice.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or visual disturbances. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid alcohol consumption while taking this medicine as it may increase the risk of stomach bleeding.
- Maintain adequate hydration.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.