Umethacin
Generic Name
Umethacin 25 mg Capsule
Manufacturer
Local Pharma Co. Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| umethacin 25 mg capsule | ৳ 0.58 | ৳ 5.80 |
Description
Overview of the medicine
Umethacin is a non-steroidal anti-inflammatory drug (NSAID) used for its analgesic, anti-inflammatory, and antipyretic properties. It is prescribed for the relief of pain and inflammation associated with various musculoskeletal conditions.
Uses & Indications
Dosage
Adults
25 mg once daily, preferably after food. Dosage may be adjusted based on patient response and tolerability, not exceeding 25 mg daily.
Elderly
Lower doses may be considered due to potential for increased sensitivity and risk of adverse effects. Careful monitoring of renal function is advised.
Renal_impairment
Use with caution. Dosage reduction may be necessary in patients with mild to moderate renal impairment. Contraindicated in severe renal impairment.
How to Take
Take the capsule orally, preferably with food or milk to minimize gastrointestinal irritation. Swallow whole with a glass of water, do not chew or crush.
Mechanism of Action
Umethacin, an oxicam derivative, primarily acts by inhibiting cyclooxygenase (COX) enzymes, particularly COX-1 and COX-2. This inhibition leads to a reduction in the synthesis of prostaglandins, which are key mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Analgesic effects may be noticeable within 30-60 minutes, while anti-inflammatory effects may take several days of continuous therapy.
Excretion
Mainly excreted in the urine (both as metabolites and unchanged drug) and to a lesser extent in feces.
Half life
Elimination half-life is relatively long, often ranging from 24 to 48 hours, supporting once-daily dosing.
Absorption
Well absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are typically reached within 2-4 hours.
Metabolism
Extensively metabolized in the liver, primarily through hydroxylation and glucuronidation.
Side Effects
Contraindications
- •Hypersensitivity to umethacin, aspirin, or other NSAIDs
- •Active gastrointestinal ulceration or bleeding
- •Severe heart failure, renal, or hepatic impairment
- •History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- •Third trimester of pregnancy
Drug Interactions
Lithium
May increase plasma lithium levels, leading to toxicity.
Methotrexate
May increase methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration and bleeding.
Diuretics and ACE Inhibitors
May reduce antihypertensive and diuretic effects; increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, lethargy, drowsiness, headache, dizziness, tinnitus, and convulsions. Management is symptomatic and supportive. Gastric lavage or activated charcoal may be considered if recent ingestion. Monitor renal and hepatic function.
Pregnancy & Lactation
Pregnancy Category C in early pregnancy, Category D in the third trimester. Avoid during the third trimester due to potential premature closure of the fetal ductus arteriosus. Use only if potential benefit justifies the potential risk to the fetus in early pregnancy. Not recommended during breastfeeding as NSAIDs can pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies
Approval Status
Approved in certain regional markets
Patent Status
Off-patent
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Global Brand Names
International brand names for this medicine
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