Unipril
Generic Name
Lisinopril
Manufacturer
Actavis Group
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| unipril 25 mg tablet | ৳ 5.03 | ৳ 50.30 |
Description
Overview of the medicine
Unipril 25 mg Tablet contains Lisinopril, an Angiotensin-Converting Enzyme (ACE) inhibitor. It is used to treat high blood pressure (hypertension), heart failure, and to improve survival after a heart attack (acute myocardial infarction). It works by relaxing blood vessels and making it easier for your heart to pump blood.
Uses & Indications
Dosage
Adults
Hypertension: Initial 10 mg once daily; usual maintenance 20-40 mg once daily. Heart Failure: Initial 2.5-5 mg once daily; usual maintenance 5-20 mg once daily. Post-MI: Initial 5 mg, then 5 mg after 24 hours, 10 mg after 48 hours, then 10 mg once daily.
Elderly
Lower initial dose may be considered, especially with impaired renal function. Usually, no specific dosage adjustment is required based on age alone.
Renal_impairment
Initial dose should be adjusted based on creatinine clearance (CrCl). For CrCl 10-30 mL/min, initial dose 2.5-5 mg once daily. For CrCl <10 mL/min, initial dose 2.5 mg once daily.
How to Take
Take Unipril 25 mg Tablet orally once daily, with or without food. It is best to take it at the same time each day.
Mechanism of Action
Lisinopril inhibits the Angiotensin-Converting Enzyme (ACE), which is responsible for converting Angiotensin I to Angiotensin II. Angiotensin II is a potent vasoconstrictor and stimulates aldosterone secretion. By inhibiting ACE, Lisinopril reduces vasoconstriction, lowers aldosterone levels, leading to decreased blood pressure and reduced cardiac preload and afterload.
Pharmacokinetics
Onset
Within 1 hour for blood pressure lowering effect.
Excretion
Excreted almost exclusively by the kidneys as the unchanged drug.
Half life
Effective half-life for accumulation is 12 hours. Terminal half-life is approximately 30 hours.
Absorption
Approximately 25-30% of an oral dose is absorbed, with variability. Absorption is not affected by food.
Metabolism
Lisinopril is not metabolized and is excreted unchanged.
Side Effects
Contraindications
- History of angioedema related to previous ACE inhibitor treatment
- Hereditary or idiopathic angioedema
- Pregnancy (especially second and third trimesters)
- Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment (GFR <60 mL/min/1.73 m²)
- Hypersensitivity to lisinopril or any other ACE inhibitor
Drug Interactions
Lithium
Increased serum lithium concentrations and lithium toxicity.
Aliskiren
Concomitant use is contraindicated in patients with diabetes or renal impairment due to increased risk of hyperkalemia, hypotension, and renal impairment.
Diuretics
Increased risk of symptomatic hypotension, especially after initiating lisinopril.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect of lisinopril and increase the risk of renal impairment.
Potassium-sparing diuretics/Potassium supplements
Increased risk of hyperkalemia.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe hypotension, electrolyte disturbances (hyperkalemia), and renal failure. Treatment is symptomatic and supportive. Intravenous saline may be administered to restore blood pressure. Lisinopril can be removed from the circulation by hemodialysis.
Pregnancy & Lactation
Unipril is contraindicated in the second and third trimesters of pregnancy due to risk of fetal injury and death. It is not recommended during the first trimester. Use in lactation is not recommended as it is excreted in breast milk.
Side Effects
Contraindications
- History of angioedema related to previous ACE inhibitor treatment
- Hereditary or idiopathic angioedema
- Pregnancy (especially second and third trimesters)
- Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment (GFR <60 mL/min/1.73 m²)
- Hypersensitivity to lisinopril or any other ACE inhibitor
Drug Interactions
Lithium
Increased serum lithium concentrations and lithium toxicity.
Aliskiren
Concomitant use is contraindicated in patients with diabetes or renal impairment due to increased risk of hyperkalemia, hypotension, and renal impairment.
Diuretics
Increased risk of symptomatic hypotension, especially after initiating lisinopril.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect of lisinopril and increase the risk of renal impairment.
Potassium-sparing diuretics/Potassium supplements
Increased risk of hyperkalemia.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe hypotension, electrolyte disturbances (hyperkalemia), and renal failure. Treatment is symptomatic and supportive. Intravenous saline may be administered to restore blood pressure. Lisinopril can be removed from the circulation by hemodialysis.
Pregnancy & Lactation
Unipril is contraindicated in the second and third trimesters of pregnancy due to risk of fetal injury and death. It is not recommended during the first trimester. Use in lactation is not recommended as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date, refer to packaging for exact date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Lisinopril has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of hypertension, heart failure, and post-myocardial infarction. These trials have established its role as a first-line agent in many of these conditions.
Lab Monitoring
- Serum potassium levels (due to risk of hyperkalemia)
- Renal function (creatinine and blood urea nitrogen - BUN)
- Blood pressure (regular monitoring)
Doctor Notes
- Before initiating Unipril, assess renal function and electrolytes.
- Monitor blood pressure regularly, especially after initial dose or dose adjustments.
- Educate patients about the risk of cough and angioedema, advising immediate medical attention if angioedema occurs.
- Avoid in pregnancy due to significant fetal risk.
Patient Guidelines
- Take the medicine regularly as prescribed by your doctor.
- Do not stop taking the medicine without consulting your doctor, even if you feel better.
- Report any swelling of the face, lips, tongue, or throat immediately to your doctor.
- Avoid potassium supplements or salt substitutes containing potassium without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Unipril may cause dizziness or fatigue, especially at the start of treatment or when changing dosage. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Adopt a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity as advised by your doctor.
- Maintain a healthy weight.
- Limit alcohol consumption and avoid smoking.
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