Uniprost
Generic Name
Latanoprost
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| uniprost 0004 eye drop | ৳ 480.00 | N/A |
Description
Overview of the medicine
Uniprost is an ophthalmic solution containing Latanoprost, used to reduce elevated intraocular pressure in patients with open-angle glaucoma and ocular hypertension.
Uses & Indications
Dosage
Adults
One drop in the affected eye(s) once daily in the evening.
Elderly
No special dosage adjustment is required for elderly patients.
Renal_impairment
No dosage adjustment is required for patients with renal impairment.
How to Take
Apply one drop into the conjunctival sac of the affected eye(s) once daily, preferably in the evening. If more than one topical ophthalmic drug is being used, they should be administered at least 5 minutes apart.
Mechanism of Action
Latanoprost is a prostaglandin F2α analogue that selectively increases the outflow of aqueous humor primarily through the uveoscleral pathway, thereby reducing intraocular pressure.
Pharmacokinetics
Onset
Onset of IOP reduction is about 3-4 hours.
Excretion
The metabolites are primarily excreted via the kidneys in urine.
Half life
The half-life of the latanoprost acid in the aqueous humor is approximately 17 minutes.
Absorption
Latanoprost is absorbed through the cornea where it is hydrolyzed to the biologically active acid form. Peak concentration in aqueous humor is reached about 2 hours after topical administration.
Metabolism
The active acid is metabolized primarily by fatty acid β-oxidation in the liver.
Side Effects
Contraindications
- Hypersensitivity to latanoprost or any other component of the formulation.
- Pregnancy (unless clearly necessary).
Drug Interactions
Other prostaglandin analogues
Concomitant use of two or more prostaglandin analogues is not recommended due to potential paradoxical increases in IOP.
Thimerosal-containing eye drops
Precipitation may occur when eye drops containing thimerosal are used in conjunction with latanoprost. If such drugs are used, they should be administered at least 5 minutes apart.
Storage
Store unopened bottles in a refrigerator (2-8°C). Once opened, store at room temperature (up to 25°C) for up to 4 weeks. Protect from light.
Overdose
Symptoms of latanoprost overdose may include ocular irritation and conjunctival hyperemia. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy: Use only if the potential benefit justifies the potential risk to the fetus. Lactation: Latanoprost and its metabolites may be excreted in human milk. Caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unopened: 24-36 months when refrigerated. Once opened: 4 weeks at room temperature.
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Patent expired; generic versions available
WHO Essential Medicine
YesClinical Trials
Latanoprost has undergone extensive clinical trials demonstrating its efficacy and safety in reducing intraocular pressure in patients with glaucoma and ocular hypertension.
Lab Monitoring
- Regular monitoring of intraocular pressure.
- Regular eye examinations to detect changes in iris pigmentation or eyelash growth.
Doctor Notes
- Emphasize strict adherence to once-daily evening dosing.
- Counsel patients on the possibility of permanent iris color change and eyelash changes.
- Monitor IOP regularly and evaluate for signs of ocular inflammation or macular edema.
Patient Guidelines
- Do not touch the dropper tip to any surface to avoid contamination.
- Remove contact lenses before administration and wait at least 15 minutes before reinserting them.
- Use consistently every evening for best results.
- Report any significant eye changes, discomfort, or side effects to your doctor.
Missed Dose Advice
If a dose is missed, continue with the next dose at the usual time. Do not double the dose to make up for a missed one.
Driving Precautions
Uniprost may cause temporary blurred vision or other visual disturbances. Patients should be cautious when driving or operating machinery until vision is clear.
Lifestyle Advice
- Maintain regular follow-up appointments with your ophthalmologist.
- Inform your doctor about all other medications you are using, including over-the-counter drugs and supplements.
- Protect your eyes from bright light if experiencing photophobia.
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Global Brand Names
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