Uniquin
Generic Name
Ofloxacin 250 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| uniquin 250 mg tablet | ৳ 1.00 | ৳ 10.00 |
Description
Overview of the medicine
Uniquin 250 mg Tablet contains Ofloxacin, a synthetic fluoroquinolone antibacterial agent. It is used to treat a wide range of bacterial infections in various parts of the body.
Uses & Indications
Dosage
Adults
Typical dose is 250 mg to 500 mg every 12 hours, depending on the type and severity of infection. For most infections, 250 mg twice daily is common.
Elderly
Dosage adjustment may be necessary based on renal function. Generally, the lowest effective dose should be used.
Renal_impairment
Dosage adjustment required. For creatinine clearance 20-50 mL/min, the dose should be reduced to 125-250 mg every 24 hours. For <20 mL/min, 125 mg every 24 hours or 250 mg every 48 hours.
How to Take
Take Uniquin 250 mg Tablet orally, with or without food. Swallow the tablet whole with water. Do not crush, chew, or break it. Avoid taking antacids, iron supplements, or dairy products within 2 hours of taking Ofloxacin.
Mechanism of Action
Ofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination. This leads to disruption of bacterial DNA and ultimately cell death.
Pharmacokinetics
Onset
Typically within 1-2 hours of administration.
Excretion
Primarily excreted unchanged in the urine (70-80% of the dose) via glomerular filtration and tubular secretion. Small amounts are excreted in feces.
Half life
Approximately 4-6 hours, allowing for twice-daily dosing.
Absorption
Rapidly and well-absorbed from the gastrointestinal tract after oral administration, with bioavailability around 98%. Peak plasma concentrations are achieved within 1-2 hours.
Metabolism
Minimally metabolized in the liver (less than 5% of dose).
Side Effects
Contraindications
- Hypersensitivity to Ofloxacin or other fluoroquinolones
- History of tendinitis or tendon rupture associated with fluoroquinolone use
- Epilepsy or other seizure disorders
- Children and adolescents (under 18 years) due to risk of joint damage
- Patients with myasthenia gravis (may exacerbate symptoms)
Drug Interactions
Warfarin
Ofloxacin may potentiate the anticoagulant effect of Warfarin, increasing the risk of bleeding. Monitor INR closely.
Theophylline
Ofloxacin can increase plasma levels of Theophylline, leading to increased risk of toxicity.
Corticosteroids
Concomitant use with corticosteroids may increase the risk of tendon rupture.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Co-administration with NSAIDs may increase the risk of CNS stimulation and convulsive seizures.
Antacids (containing magnesium, aluminum), Sucralfate, Iron/Zinc supplements
Can significantly reduce the absorption of Ofloxacin. Administer Ofloxacin at least 2 hours before or 6 hours after these agents.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include CNS symptoms such as confusion, dizziness, impaired consciousness, convulsive seizures, and gastrointestinal reactions like nausea and erosion of the gastric mucosa. In case of overdose, gastric lavage may be considered. Symptomatic and supportive treatment should be initiated. Monitor vital signs and ECG.
Pregnancy & Lactation
Pregnancy Category C. Ofloxacin should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus. It is excreted into breast milk and is therefore not recommended during breastfeeding due to potential harm to the infant, including interference with cartilage development.
Side Effects
Contraindications
- Hypersensitivity to Ofloxacin or other fluoroquinolones
- History of tendinitis or tendon rupture associated with fluoroquinolone use
- Epilepsy or other seizure disorders
- Children and adolescents (under 18 years) due to risk of joint damage
- Patients with myasthenia gravis (may exacerbate symptoms)
Drug Interactions
Warfarin
Ofloxacin may potentiate the anticoagulant effect of Warfarin, increasing the risk of bleeding. Monitor INR closely.
Theophylline
Ofloxacin can increase plasma levels of Theophylline, leading to increased risk of toxicity.
Corticosteroids
Concomitant use with corticosteroids may increase the risk of tendon rupture.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Co-administration with NSAIDs may increase the risk of CNS stimulation and convulsive seizures.
Antacids (containing magnesium, aluminum), Sucralfate, Iron/Zinc supplements
Can significantly reduce the absorption of Ofloxacin. Administer Ofloxacin at least 2 hours before or 6 hours after these agents.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include CNS symptoms such as confusion, dizziness, impaired consciousness, convulsive seizures, and gastrointestinal reactions like nausea and erosion of the gastric mucosa. In case of overdose, gastric lavage may be considered. Symptomatic and supportive treatment should be initiated. Monitor vital signs and ECG.
Pregnancy & Lactation
Pregnancy Category C. Ofloxacin should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus. It is excreted into breast milk and is therefore not recommended during breastfeeding due to potential harm to the infant, including interference with cartilage development.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA, FDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Ofloxacin has undergone extensive clinical trials to establish its efficacy and safety profile for various bacterial infections. Ongoing post-marketing surveillance continues to monitor its effects.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, BUN) in patients with impaired renal function
- Blood glucose monitoring in diabetic patients
- INR monitoring for patients on warfarin
- Liver function tests (LFTs) in cases of prolonged therapy or suspected hepatic dysfunction
Doctor Notes
- Emphasize the importance of completing the full course of treatment to prevent resistance.
- Advise patients to report any musculoskeletal pain or neurological symptoms immediately.
- Be aware of potential drug interactions, especially with antacids, warfarin, and NSAIDs.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if you feel better, to prevent the development of antibiotic resistance.
- Stay well-hydrated while taking this medication.
- Avoid excessive exposure to sunlight or artificial UV light, as Ofloxacin can increase sensitivity to light. Use sunscreen and wear protective clothing.
- Report any pain, swelling, or inflammation of tendons (especially in the ankle, wrist, shoulder) immediately to your doctor.
- Do not drive or operate machinery if you experience dizziness, lightheadedness, or visual disturbances.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Uniquin 250 mg Tablet may cause dizziness, lightheadedness, visual disturbances, or confusion in some individuals. Patients should be cautioned against driving or operating hazardous machinery until they are reasonably certain that Ofloxacin does not adversely affect their ability to engage in such activities.
Lifestyle Advice
- Maintain good hygiene to prevent infections.
- Consume a balanced diet.
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