Univer
Generic Name
univer-12-mg-tablet
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| univer 12 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Univer 12 mg tablet is an anti-inflammatory and analgesic medication used to relieve pain and reduce inflammation in various conditions. It works by inhibiting specific enzymes involved in the body's inflammatory response.
Uses & Indications
Dosage
Adults
12 mg once daily, or as directed by physician. Maximum daily dose is 12 mg.
Elderly
Initiate with lowest effective dose, monitor renal function. Generally, 12 mg once daily is acceptable.
Renal_impairment
Use with caution. Dosage reduction may be necessary for severe renal impairment (CrCl < 30 mL/min).
How to Take
Take orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water.
Mechanism of Action
Univer-12-mg-tablet selectively inhibits cyclooxygenase-2 (COX-2) enzyme, which is responsible for the synthesis of prostaglandins involved in pain and inflammation. This inhibition leads to reduced pain and inflammation.
Pharmacokinetics
Onset
Onset of action within 30-60 minutes for analgesic effect.
Excretion
Mainly excreted in urine (approx. 70%) and feces (approx. 30%) as metabolites.
Half life
Elimination half-life typically ranges from 12-15 hours.
Absorption
Well absorbed orally, with peak plasma concentrations reached within 2-4 hours after administration.
Metabolism
Primarily metabolized in the liver via cytochrome P450 enzymes.
Side Effects
Contraindications
- Hypersensitivity to the active substance or any excipients
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe hepatic or renal impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain. Management includes symptomatic and supportive care. Gastric lavage or activated charcoal may be considered within the first hour of ingestion.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to risk of premature closure of the ductus arteriosus. Use with caution during first and second trimesters only if potential benefit justifies potential risk to the fetus. Not recommended during breastfeeding as it may pass into breast milk.
Side Effects
Contraindications
- Hypersensitivity to the active substance or any excipients
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe hepatic or renal impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain. Management includes symptomatic and supportive care. Gastric lavage or activated charcoal may be considered within the first hour of ingestion.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to risk of premature closure of the ductus arteriosus. Use with caution during first and second trimesters only if potential benefit justifies potential risk to the fetus. Not recommended during breastfeeding as it may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have demonstrated efficacy and safety in various pain and inflammatory conditions. Further trials are ongoing to explore new indications.
Lab Monitoring
- Complete Blood Count (CBC)
- Liver Function Tests (LFTs)
- Renal Function Tests (RFTs)
- Blood pressure monitoring
Doctor Notes
- Advise patients to take with food to minimize GI adverse effects.
- Monitor renal function and blood pressure, especially in elderly or those with pre-existing conditions.
- Educate on symptoms of GI bleeding and cardiovascular events.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Report any unusual bleeding or persistent stomach upset immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness or drowsiness in some individuals. If affected, avoid driving or operating heavy machinery.
Lifestyle Advice
- Avoid alcohol consumption while on this medication.
- Maintain a healthy diet and stay hydrated.
- Consult your doctor before taking any over-the-counter pain relievers.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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