Urbifen
Generic Name
Flurbiprofen
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| urbifen 50 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Urbifen 50 mg Tablet contains Flurbiprofen, a non-steroidal anti-inflammatory drug (NSAID) used for the relief of pain, inflammation, and stiffness caused by various conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute musculoskeletal disorders, and dysmenorrhea.
Uses & Indications
Dosage
Adults
The usual adult dosage is 150-200 mg daily, taken in divided doses (e.g., 50 mg three to four times a day). Maximum recommended daily dose is 300 mg. For dysmenorrhea, 100 mg initially, then 50-100 mg every 4-6 hours as needed.
Elderly
Lower doses may be required, and patients should be monitored for adverse effects due to increased risk.
Renal_impairment
Use with caution; dose reduction may be necessary in moderate to severe renal impairment. Avoid in severe renal failure.
Hepatic_impairment
Use with caution; dose reduction may be necessary in moderate to severe hepatic impairment. Avoid in severe hepatic failure.
How to Take
Take Urbifen tablet orally, preferably with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water, do not chew or crush.
Mechanism of Action
Flurbiprofen inhibits prostaglandin synthesis by blocking the enzyme cyclooxygenase (COX-1 and COX-2). This reduction in prostaglandin levels is responsible for its analgesic, anti-inflammatory, and antipyretic effects.
Pharmacokinetics
Onset
Within 30-60 minutes for analgesia; several days to weeks for full anti-inflammatory effect.
Excretion
Mainly excreted in urine as metabolites (up to 95%), with a small amount excreted in feces.
Half life
Approximately 3-6 hours.
Absorption
Well absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 1-2 hours.
Metabolism
Extensively metabolized in the liver, primarily via cytochrome P450 2C9 (CYP2C9), to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to flurbiprofen or any other NSAIDs (e.g., aspirin)
- Active peptic ulceration or gastrointestinal bleeding
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
May increase plasma lithium levels, leading to toxicity.
Methotrexate
May increase methotrexate plasma levels, leading to toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Other NSAIDs or Aspirin
Increased risk of adverse effects, especially GI.
Diuretics and ACE inhibitors
May reduce the hypotensive effect of these drugs and increase the risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, drowsiness, and occasionally gastrointestinal bleeding. Rarely, hypertension, acute renal failure, respiratory depression, and coma may occur. Management is symptomatic and supportive. Gastric lavage or activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C in the first and second trimesters, Category D in the third trimester. Use is not recommended during the third trimester of pregnancy due to potential fetal harm (e.g., premature closure of the ductus arteriosus). Flurbiprofen is excreted in breast milk, so it is generally not recommended for use during lactation.
Side Effects
Contraindications
- Hypersensitivity to flurbiprofen or any other NSAIDs (e.g., aspirin)
- Active peptic ulceration or gastrointestinal bleeding
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
May increase plasma lithium levels, leading to toxicity.
Methotrexate
May increase methotrexate plasma levels, leading to toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Other NSAIDs or Aspirin
Increased risk of adverse effects, especially GI.
Diuretics and ACE inhibitors
May reduce the hypotensive effect of these drugs and increase the risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, drowsiness, and occasionally gastrointestinal bleeding. Rarely, hypertension, acute renal failure, respiratory depression, and coma may occur. Management is symptomatic and supportive. Gastric lavage or activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C in the first and second trimesters, Category D in the third trimester. Use is not recommended during the third trimester of pregnancy due to potential fetal harm (e.g., premature closure of the ductus arteriosus). Flurbiprofen is excreted in breast milk, so it is generally not recommended for use during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 36 months from the date of manufacture. Refer to the packaging for exact expiry.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available
Clinical Trials
Flurbiprofen has undergone extensive clinical trials demonstrating its efficacy and safety in various pain and inflammatory conditions. Ongoing research may explore new indications or formulations.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, BUN) periodically, especially with long-term use or in patients with impaired renal function.
- Liver function tests (e.g., ALT, AST) periodically.
- Complete blood count (CBC) with differential, especially with long-term therapy, to monitor for anemia or other blood dyscrasias.
Doctor Notes
- Consider lowest effective dose for shortest duration to minimize risks.
- Monitor renal function, liver function, and blood pressure in patients on long-term therapy.
- Educate patients on symptoms of GI bleeding and cardiovascular events.
- Exercise caution in elderly patients and those with pre-existing cardiovascular or renal conditions.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Take with food or milk to reduce stomach upset.
- Do not exceed the recommended dose.
- Inform your doctor about any pre-existing medical conditions or other medications you are taking.
- Report any unusual bleeding, stomach pain, black stools, or severe rash immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Flurbiprofen may cause dizziness, drowsiness, or visual disturbances in some patients. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Avoid alcohol consumption while taking this medication, as it may increase the risk of gastrointestinal side effects.
- Maintain adequate hydration.
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