Uricare-SR
Generic Name
Tamsulosin Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| uricare sr 04 mg capsule | ৳ 10.00 | ৳ 60.00 |
Description
Overview of the medicine
Uricare-SR 0.4 mg Capsule contains Tamsulosin Hydrochloride, an alpha-1 blocker used to treat the signs and symptoms of Benign Prostatic Hyperplasia (BPH). It helps relax the muscles in the prostate and bladder neck, improving urine flow.
Uses & Indications
Dosage
Adults
0.4 mg once daily, taken approximately 30 minutes after the same meal each day. May be increased to 0.8 mg once daily after 2-4 weeks if necessary.
Elderly
No dosage adjustment is generally required for elderly patients.
Renal_impairment
No dosage adjustment is generally required for patients with mild to moderate renal impairment. Caution is advised in severe renal impairment (CrCl < 10 mL/min).
How to Take
Take orally once daily, approximately 30 minutes after the same meal each day. The capsule should be swallowed whole; do not crush, chew, or open it.
Mechanism of Action
Tamsulosin selectively and competitively blocks alpha-1A and alpha-1D adrenergic receptors located in the prostatic stromal smooth muscle, bladder neck, and prostatic urethra. This blockade causes relaxation of the smooth muscles in these areas, thereby decreasing urethral resistance and improving urine flow and reducing BPH symptoms.
Pharmacokinetics
Onset
Clinical effects seen within 4-8 hours; full effect may take 2-4 weeks.
Excretion
Excreted mainly in the urine (76% of dose) and faeces (21% of dose) as metabolites.
Half life
Approximately 9-15 hours in healthy volunteers, and around 14-15 hours in the target population.
Absorption
Well absorbed from the gastrointestinal tract, especially after food. Bioavailability is nearly 90%.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4 and CYP2D6 enzymes.
Side Effects
Contraindications
- Hypersensitivity to tamsulosin hydrochloride or any component of the formulation
- History of orthostatic hypotension
- Severe hepatic impairment
Drug Interactions
Other alpha-adrenergic blockers
Increased risk of hypotension. Should not be used in combination.
Strong CYP2D6 inhibitors (e.g., paroxetine)
May increase tamsulosin exposure. Concomitant use should be used with caution.
PDE5 inhibitors (e.g., sildenafil, tadalafil)
Increased risk of hypotension, especially orthostatic hypotension. Use with caution.
Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
May increase tamsulosin exposure, leading to increased risk of adverse effects. Concomitant use should be avoided or used with caution at reduced dosage.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to severe hypotensive effects. Management involves supportive measures, including keeping the patient supine, fluid replacement, and if necessary, vasopressors.
Pregnancy & Lactation
Tamsulosin is not indicated for use in women. Therefore, it is not relevant for pregnancy and lactation.
Side Effects
Contraindications
- Hypersensitivity to tamsulosin hydrochloride or any component of the formulation
- History of orthostatic hypotension
- Severe hepatic impairment
Drug Interactions
Other alpha-adrenergic blockers
Increased risk of hypotension. Should not be used in combination.
Strong CYP2D6 inhibitors (e.g., paroxetine)
May increase tamsulosin exposure. Concomitant use should be used with caution.
PDE5 inhibitors (e.g., sildenafil, tadalafil)
Increased risk of hypotension, especially orthostatic hypotension. Use with caution.
Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
May increase tamsulosin exposure, leading to increased risk of adverse effects. Concomitant use should be avoided or used with caution at reduced dosage.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to severe hypotensive effects. Management involves supportive measures, including keeping the patient supine, fluid replacement, and if necessary, vasopressors.
Pregnancy & Lactation
Tamsulosin is not indicated for use in women. Therefore, it is not relevant for pregnancy and lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Expired (Generic available)
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of tamsulosin in improving urinary symptoms associated with BPH.
Lab Monitoring
- Blood pressure monitoring (especially initial doses)
- Renal function (if severe impairment)
Doctor Notes
- Advise patients about potential orthostatic hypotension and to be cautious when changing posture.
- Remind patients to inform ophthalmologists about tamsulosin use before cataract or glaucoma surgery.
- Emphasize the importance of taking the medicine consistently after a meal at the same time each day.
Patient Guidelines
- Take the capsule whole, do not crush or chew.
- Take it approximately 30 minutes after the same meal each day to maintain consistent drug levels.
- Be aware of potential dizziness or lightheadedness, especially when standing up from a sitting or lying position.
- Inform your doctor if you are planning cataract or glaucoma surgery, as this medicine may cause Intraoperative Floppy Iris Syndrome (IFIS).
Missed Dose Advice
If a dose is missed, take it with the next meal. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness, especially at the start of treatment or when changing dosage. Patients should be warned about driving or operating machinery until they know how Uricare-SR affects them.
Lifestyle Advice
- Avoid sudden changes in posture to minimize the risk of dizziness.
- Maintain adequate hydration.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.