Uride
Generic Name
uride-850-mg-tablet
Manufacturer
Generic Pharmaceuticals
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| uride 850 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Uride 850 mg tablet contains Metformin Hydrochloride, an oral antidiabetic drug used to manage type 2 diabetes mellitus. It helps to lower blood glucose levels by reducing glucose production in the liver, decreasing glucose absorption from the intestines, and improving the body's sensitivity to insulin.
Uses & Indications
Dosage
Adults
Initially, 500 mg twice daily or 850 mg once daily with meals. The dose may be gradually increased by 500 mg weekly or 850 mg every 2 weeks to a maximum of 2550 mg per day. For 850 mg tablet: 850 mg once or twice daily with meals. Take with food to minimize gastrointestinal side effects.
Elderly
Dosage should be individualized and renal function monitored due to potential for decreased renal function. Start with a conservative dose and titrate cautiously.
Renal_impairment
Not recommended if eGFR < 30 mL/min/1.73m². Dose adjustment is required for eGFR 30-45 mL/min/1.73m². Regular monitoring of renal function is essential.
How to Take
Uride 850 mg tablet should be taken orally with meals, typically once or twice daily as prescribed by the doctor. Taking it with food helps to reduce gastrointestinal side effects.
Mechanism of Action
Metformin works by reducing hepatic glucose production, decreasing intestinal absorption of glucose, and improving insulin sensitivity by increasing peripheral glucose uptake and utilization. It does not stimulate insulin secretion and therefore does not cause hypoglycemia in monotherapy.
Pharmacokinetics
Onset
Onset of glucose-lowering effect is typically within 1-3 hours.
Excretion
Metformin is primarily excreted unchanged in the urine. Renal clearance is approximately 3.5 times higher than creatinine clearance, indicating tubular secretion.
Half life
The plasma elimination half-life of Metformin is approximately 4-9 hours.
Absorption
Absolute bioavailability of an 850 mg Metformin tablet is approximately 50-60%. Food slightly decreases the extent and delays the absorption of Metformin.
Metabolism
Metformin is not metabolized in humans.
Side Effects
Contraindications
- •Severe renal impairment (eGFR < 30 mL/min/1.73m²).
- •Metabolic acidosis, including diabetic ketoacidosis, with or without coma.
- •Known hypersensitivity to metformin hydrochloride or any component of the formulation.
- •Acute or chronic disease which may cause tissue hypoxia (e.g., cardiac or respiratory failure, recent myocardial infarction, shock).
- •Acute alcohol intoxication.
Drug Interactions
Alcohol
Potentiates the effect of metformin on lactate metabolism, increasing the risk of lactic acidosis. Advise patients to avoid excessive alcohol intake while taking metformin.
Cimetidine
May increase metformin plasma concentration, potentially increasing the risk of lactic acidosis. Monitor patients closely.
Iodinated Contrast Agents
Temporarily discontinue metformin before or at the time of the imaging procedure in patients with an eGFR between 30 and 60 mL/min/1.73m², patients with a history of liver disease, alcoholism, or heart failure, or patients who will be administered intra-arterial iodinated contrast. Re-evaluate eGFR 48 hours after the imaging procedure and restart metformin if renal function is stable.
Carbonic Anhydrase Inhibitors (e.g., Topiramate, Acetazolamide)
May increase the risk of lactic acidosis. Consider more frequent monitoring of these patients.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Overdose of Metformin primarily leads to lactic acidosis, which is a medical emergency requiring immediate treatment. Symptoms include severe gastrointestinal upset, muscle pain, difficulty breathing, lethargy, and hypothermia. Management involves supportive care and immediate hemodialysis, which is highly effective in removing metformin from the body.
Pregnancy & Lactation
Pregnancy Category B. Limited data suggest it is generally safe during pregnancy, particularly for gestational diabetes or PCOS, but always consult a doctor. Metformin is excreted into breast milk in small amounts; generally considered compatible with breastfeeding, but monitor the infant for adverse effects. Consult a healthcare professional.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture, specific to the manufacturer's guidelines.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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