Urikal
Generic Name
Potassium Citrate 1500 mg Oral Solution
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| urikal 1500 mg oral solution | ৳ 120.00 | N/A |
Description
Overview of the medicine
Urikal 1500 mg Oral Solution contains potassium citrate, used to treat certain kidney stone conditions and metabolic acidosis. It works by making the urine less acidic, which helps prevent the formation of new kidney stones and can dissolve existing uric acid stones.
Uses & Indications
Dosage
Adults
Typically 10-20 mEq (1100-2200 mg) three to four times daily, adjusted to maintain urinary pH between 6.0-7.0. For 1500mg (approx 15 mEq), it could be 1-2 pouches daily.
Elderly
Similar to adult dosage, with careful monitoring of renal function.
Renal_impairment
Contraindicated in severe renal impairment. In mild to moderate impairment, use with caution and frequent monitoring of serum electrolytes and renal function.
How to Take
Dissolve the contents of the sachet in a glass of water (100-200 ml) and take orally, preferably with or after meals. Drink plenty of water throughout the day.
Mechanism of Action
Potassium citrate is metabolized in the body to bicarbonate, which increases the pH of the urine and raises urinary citrate levels. Elevated urinary citrate binds with calcium, preventing its crystallization, while the increased pH helps in the dissolution of uric acid stones and prevents new formation.
Pharmacokinetics
Onset
Within hours of administration, urinary pH changes become apparent.
Excretion
Excreted primarily via the kidneys as citrate or after metabolism as bicarbonate.
Half life
Approximately 20-30 minutes (for citrate, potassium kinetics differ slightly)
Absorption
Readily absorbed from the gastrointestinal tract.
Metabolism
Citrate is metabolized to bicarbonate in the liver.
Side Effects
Contraindications
- Severe renal impairment (glomerular filtration rate less than 0.7 ml/min/1.73m2)
- Untreated Addison's disease
- Hyperkalemia or conditions predisposing to hyperkalemia (e.g., severe myocardial damage, acute dehydration)
- Active urinary tract infection
- Gastric ulceration
- Bowel obstruction
Drug Interactions
Anticholinergics
May increase the risk of gastrointestinal irritation due to slower transit time.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce renal potassium excretion and increase risk of hyperkalemia.
ACE inhibitors and Angiotensin Receptor Blockers (ARBs)
May increase serum potassium levels.
Potassium-sparing diuretics (e.g., spironolactone, triamterene)
Increased risk of hyperkalemia.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include hyperkalemia and metabolic alkalosis. Management involves discontinuing the drug, monitoring serum electrolytes, and providing supportive care. In severe cases, intravenous calcium gluconate, insulin/glucose, or hemodialysis may be required for hyperkalemia.
Pregnancy & Lactation
Use with caution during pregnancy only if clearly needed and the benefits outweigh the risks. Limited data on excretion in breast milk; use with caution in lactating mothers.
Side Effects
Contraindications
- Severe renal impairment (glomerular filtration rate less than 0.7 ml/min/1.73m2)
- Untreated Addison's disease
- Hyperkalemia or conditions predisposing to hyperkalemia (e.g., severe myocardial damage, acute dehydration)
- Active urinary tract infection
- Gastric ulceration
- Bowel obstruction
Drug Interactions
Anticholinergics
May increase the risk of gastrointestinal irritation due to slower transit time.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce renal potassium excretion and increase risk of hyperkalemia.
ACE inhibitors and Angiotensin Receptor Blockers (ARBs)
May increase serum potassium levels.
Potassium-sparing diuretics (e.g., spironolactone, triamterene)
Increased risk of hyperkalemia.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include hyperkalemia and metabolic alkalosis. Management involves discontinuing the drug, monitoring serum electrolytes, and providing supportive care. In severe cases, intravenous calcium gluconate, insulin/glucose, or hemodialysis may be required for hyperkalemia.
Pregnancy & Lactation
Use with caution during pregnancy only if clearly needed and the benefits outweigh the risks. Limited data on excretion in breast milk; use with caution in lactating mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic/Off-patent
Clinical Trials
Numerous clinical trials have established the efficacy and safety of potassium citrate in preventing kidney stone recurrence and managing related conditions.
Lab Monitoring
- Serum electrolytes (especially potassium)
- Renal function (BUN, creatinine)
- Urinary pH
- Urinary citrate levels
Doctor Notes
- Regular monitoring of serum potassium, creatinine, and urinary pH is crucial during treatment.
- Advise patients on adequate fluid intake and dietary modifications.
- Consider drug interactions, especially with ACE inhibitors, ARBs, and potassium-sparing diuretics.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Dissolve the entire sachet contents in a full glass of water.
- Drink plenty of fluids throughout the day to help prevent kidney stones.
- Report any severe stomach pain, black stools, or weakness immediately to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Urikal is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain adequate fluid intake.
- Avoid excessive salt intake.
- Follow a balanced diet rich in fruits and vegetables.
- Regular exercise.
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