Urilizer
Generic Name
Urilizer 1500 mg Oral Solution
Manufacturer
MediCorp Pharma
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| urilizer 1500 mg oral solution | ৳ 200.00 | N/A |
Description
Overview of the medicine
Urilizer 1500 mg Oral Solution is used to prevent and treat certain types of kidney stones (e.g., uric acid and cystine stones) by increasing the pH of urine, making it more alkaline.
Uses & Indications
Dosage
Adults
Typically, 1-2 tablespoons (15-30 mL) diluted in water, 2-3 times daily, preferably after meals. Adjust dose to maintain urine pH between 6.5 and 7.5.
Elderly
Similar to adult dosage, but caution is advised, and renal function should be closely monitored due to potential age-related decline in kidney function.
Renal_impairment
Dose adjustment is necessary for patients with impaired renal function. Contraindicated in severe renal impairment. Consult a physician for specific dosing.
How to Take
Take orally, diluted in a full glass of water, preferably after meals to minimize gastrointestinal irritation. Use a measuring spoon or cup for accurate dosing.
Mechanism of Action
This medicine acts as a systemic alkalizer. It works by increasing the urinary pH, making the urine less acidic. This process helps to dissolve uric acid and cystine stones and prevents their formation by increasing the solubility of uric acid and inhibiting the crystallization of cystine.
Pharmacokinetics
Onset
Onset of action typically occurs within 1-2 hours after administration.
Excretion
Excreted mainly through the kidneys, with a significant portion appearing as unchanged drug or metabolites in the urine.
Half life
The half-life is approximately 2-3 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are achieved within 1-2 hours.
Metabolism
Primarily metabolized in the liver.
Side Effects
Contraindications
- •Severe renal impairment (glomerular filtration rate < 30 mL/min)
- •Hyperkalemia or conditions predisposing to hyperkalemia (e.g., Addison's disease, acute dehydration, extensive tissue damage)
- •Untreated peptic ulcer disease
- •Active urinary tract infection (unless concurrent appropriate antibiotic therapy is administered)
- •Any condition where potassium or sodium retention is contraindicated
Drug Interactions
Aluminium-containing antacids
Increased absorption of aluminium, potentially leading to aluminium toxicity.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce renal potassium excretion, increasing the risk of hyperkalemia.
ACE inhibitors and Angiotensin Receptor Blockers (ARBs)
Increased risk of hyperkalemia.
Potassium-sparing diuretics (e.g., spironolactone, amiloride)
Concomitant use may lead to severe hyperkalemia.
Storage
Store in a cool and dry place, below 25°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe hyperkalemia (e.g., muscle weakness, paresthesia, fatigue, ECG changes) and metabolic alkalosis. Management involves discontinuing the drug, monitoring electrolytes, and supportive care. In severe cases, dialysis may be required.
Pregnancy & Lactation
Category C. Use during pregnancy and lactation only if clearly needed and the potential benefits outweigh the potential risks to the fetus or infant. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent pending
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Global Brand Names
International brand names for this medicine
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