Urinom
Generic Name
Tamsulosin Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| urinom 04 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Tamsulosin is an alpha-blocker used to treat symptoms of an enlarged prostate (benign prostatic hyperplasia or BPH) such as difficulty urinating, weak stream, and frequent urination. It works by relaxing muscles in the prostate and bladder neck.
Uses & Indications
Dosage
Adults
0.4 mg once daily, taken approximately 30 minutes after the same meal each day. May be increased to 0.8 mg once daily after 2-4 weeks if necessary.
Elderly
No dosage adjustment is generally required.
Renal_impairment
No dosage adjustment is generally required for mild to moderate impairment; use with caution in severe impairment.
How to Take
Take orally, once daily, approximately 30 minutes after the same meal each day. Do not crush, chew, or open the tablet.
Mechanism of Action
Tamsulosin selectively and competitively binds to alpha-1A adrenergic receptors in the prostate, bladder neck, and prostatic urethra, causing relaxation of the smooth muscle in these tissues. This decreases outflow obstruction and improves urine flow.
Pharmacokinetics
Onset
Symptomatic improvement within 1-2 weeks, full effect may take longer.
Excretion
Primarily via urine (76%) and feces (21%) as metabolites and unchanged drug.
Half life
Approximately 9-15 hours.
Absorption
Well absorbed from the gastrointestinal tract, nearly 90% bioavailable. Food affects absorption; typically taken 30 minutes after the same meal each day.
Metabolism
Primarily hepatic, extensive metabolism by CYP3A4 and CYP2D6.
Side Effects
Contraindications
- Hypersensitivity to tamsulosin or any component of the formulation.
- History of orthostatic hypotension.
- Severe hepatic impairment.
Drug Interactions
Strong CYP2D6 inhibitors (e.g., paroxetine)
May increase tamsulosin exposure.
PDE5 inhibitors (e.g., sildenafil, tadalafil)
Increased risk of hypotension.
Strong CYP3A4 inhibitors (e.g., ketoconazole)
May increase tamsulosin exposure.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include severe hypotension and compensatory tachycardia. Treatment is supportive; vasopressors may be used if needed.
Pregnancy & Lactation
Not indicated for use in women.
Side Effects
Contraindications
- Hypersensitivity to tamsulosin or any component of the formulation.
- History of orthostatic hypotension.
- Severe hepatic impairment.
Drug Interactions
Strong CYP2D6 inhibitors (e.g., paroxetine)
May increase tamsulosin exposure.
PDE5 inhibitors (e.g., sildenafil, tadalafil)
Increased risk of hypotension.
Strong CYP3A4 inhibitors (e.g., ketoconazole)
May increase tamsulosin exposure.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include severe hypotension and compensatory tachycardia. Treatment is supportive; vasopressors may be used if needed.
Pregnancy & Lactation
Not indicated for use in women.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of tamsulosin in treating BPH symptoms.
Lab Monitoring
- No specific routine lab monitoring is required. Prostate-specific antigen (PSA) levels should be monitored as per standard BPH management guidelines.
Doctor Notes
- Advise patients about the risk of orthostatic hypotension and IFIS.
- Ensure patients are aware of the importance of taking the medication consistently with food.
Patient Guidelines
- Take the medicine after the same meal each day.
- Do not crush or chew the tablet.
- Be aware of potential dizziness or lightheadedness, especially when standing up from a sitting or lying position.
Missed Dose Advice
If a dose is missed, take it at the next scheduled time with food. Do not double the dose.
Driving Precautions
May cause dizziness or lightheadedness, especially at the start of treatment or when changing dose. Patients should be cautioned about driving or operating machinery.
Lifestyle Advice
- Avoid sudden changes in position to minimize dizziness.
- Maintain a healthy diet and regular exercise.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.