Urivent
Generic Name
Alfuzosin Hydrochloride Extended Release
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| urivent 04 mg capsule | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Urivent 0.4 mg Capsule contains Alfuzosin, an alpha-1 adrenoceptor antagonist used to treat the symptoms of benign prostatic hyperplasia (BPH) by relaxing muscles in the prostate and bladder neck, thus improving urine flow.
Uses & Indications
Dosage
Adults
One 0.4 mg extended-release capsule once daily immediately after the same meal each day. The capsule should be swallowed whole and not crushed or chewed.
Elderly
No dose adjustment is generally required in elderly patients, but caution is advised in those with severe renal or hepatic impairment.
Renal_impairment
No dose adjustment is generally necessary for patients with mild to moderate renal impairment. Caution is advised in severe renal impairment (creatinine clearance <30 mL/min).
How to Take
Take orally, once daily, immediately after the same meal each day. The capsule must be swallowed whole with water and should not be crushed, chewed, or divided.
Mechanism of Action
Alfuzosin selectively blocks alpha-1 adrenoceptors in the smooth muscle of the prostate, bladder neck, and prostatic urethra. This blockade leads to relaxation of these smooth muscles, reducing the resistance to urine flow and alleviating the symptoms associated with BPH.
Pharmacokinetics
Onset
Symptomatic improvement may occur within days to weeks of starting treatment.
Excretion
Approximately 69% excreted in feces and 11% in urine.
Half life
Approximately 4-6 hours (for extended-release formulation).
Absorption
Well absorbed from the gastrointestinal tract; absorption is increased when taken with food. Peak plasma concentrations are reached approximately 6-8 hours after administration.
Metabolism
Extensively metabolized in the liver, primarily via CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to alfuzosin or any of the excipients.
- History of orthostatic hypotension.
- Severe hepatic impairment (Child-Pugh Class C).
- Concomitant use with other alpha-1 adrenoceptor antagonists.
Drug Interactions
Nitrates
Potentiation of hypotensive effects, concurrent use is not recommended.
Antihypertensive medications
Increased risk of hypotension. Blood pressure should be monitored.
Other alpha-1 adrenoceptor antagonists (e.g., Tamsulosin, Doxazosin)
Increased risk of hypotension due to additive hypotensive effects.
Strong CYP3A4 inhibitors (e.g., Ketoconazole, Itraconazole, Ritonavir)
Increased plasma concentrations of alfuzosin, increasing the risk of adverse effects including hypotension.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to hypotension. Management involves placing the patient in a supine position, administering intravenous fluids, and if necessary, using vasopressors (e.g., norepinephrine) to restore blood pressure. Dialysis is unlikely to be beneficial due to high protein binding.
Pregnancy & Lactation
Urivent (Alfuzosin) is not indicated for use in women. Therefore, information regarding pregnancy and lactation is not applicable.
Side Effects
Contraindications
- Hypersensitivity to alfuzosin or any of the excipients.
- History of orthostatic hypotension.
- Severe hepatic impairment (Child-Pugh Class C).
- Concomitant use with other alpha-1 adrenoceptor antagonists.
Drug Interactions
Nitrates
Potentiation of hypotensive effects, concurrent use is not recommended.
Antihypertensive medications
Increased risk of hypotension. Blood pressure should be monitored.
Other alpha-1 adrenoceptor antagonists (e.g., Tamsulosin, Doxazosin)
Increased risk of hypotension due to additive hypotensive effects.
Strong CYP3A4 inhibitors (e.g., Ketoconazole, Itraconazole, Ritonavir)
Increased plasma concentrations of alfuzosin, increasing the risk of adverse effects including hypotension.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to hypotension. Management involves placing the patient in a supine position, administering intravenous fluids, and if necessary, using vasopressors (e.g., norepinephrine) to restore blood pressure. Dialysis is unlikely to be beneficial due to high protein binding.
Pregnancy & Lactation
Urivent (Alfuzosin) is not indicated for use in women. Therefore, information regarding pregnancy and lactation is not applicable.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture, depending on the manufacturer.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent
Clinical Trials
Alfuzosin has undergone extensive clinical trials demonstrating its efficacy and safety in improving LUTS associated with BPH. Key trials focused on its extended-release formulation for once-daily dosing.
Lab Monitoring
- No specific routine laboratory monitoring is required for alfuzosin.
- Monitor blood pressure regularly, especially at the start of treatment and dose escalation.
Doctor Notes
- Advise patients to take Urivent after a meal to optimize absorption and reduce the risk of orthostatic hypotension.
- Caution in patients with prolonged QT interval or taking medications that prolong QT interval.
- Patients undergoing cataract surgery should inform their ophthalmologist about alfuzosin use due to the risk of Intraoperative Floppy Iris Syndrome (IFIS).
Patient Guidelines
- Take the capsule whole with food, do not crush or chew.
- Be aware of potential dizziness or lightheadedness, especially when standing up from a sitting or lying position.
- Inform your doctor if you experience prolonged, painful erection (priapism).
- Inform your ophthalmologist about alfuzosin use before any eye surgery.
Missed Dose Advice
If a dose is missed, do not take a double dose to make up for it. Simply take the next dose at the regular scheduled time with your next meal.
Driving Precautions
May cause dizziness, lightheadedness, or weakness, particularly at the beginning of treatment. Patients should be warned about these potential effects and advised not to drive or operate machinery if affected.
Lifestyle Advice
- Avoid sudden changes in posture to minimize the risk of dizziness or lightheadedness.
- Maintain adequate hydration.
- Limit alcohol intake as it may enhance hypotensive effects.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.