Urocure SR
Generic Name
Alfuzosin Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| urocure sr 100 mg capsule | ৳ 20.06 | ৳ 200.60 |
Description
Overview of the medicine
Alfuzosin is an alpha-1 adrenergic blocker used to treat the symptoms of benign prostatic hyperplasia (BPH) by relaxing muscles in the prostate and bladder neck, thereby improving urine flow and reducing bladder outflow obstruction.
Uses & Indications
Dosage
Adults
10 mg once daily, immediately after the same meal each day.
Elderly
No specific dose adjustment is generally required, but caution is advised due to potential for increased sensitivity.
Renal_impairment
Mild to moderate renal impairment (CrCl ≥30 mL/min): No dose adjustment needed. Severe renal impairment (CrCl <30 mL/min): Use with caution, consider alternative treatments.
How to Take
Swallow the tablet whole with water, do not crush, chew, or divide. Take immediately after the same meal each day.
Mechanism of Action
Alfuzosin selectively blocks alpha-1 adrenergic receptors located in the prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra. This blockade causes relaxation of the smooth muscle in these tissues, reducing urethral resistance and improving urine flow in BPH patients.
Pharmacokinetics
Onset
Symptomatic relief within hours to days, full therapeutic effect may take several weeks.
Excretion
Mainly excreted in feces (75-91%), with a smaller amount (approximately 11%) excreted in urine.
Half life
Approximately 5 to 8 hours (for the sustained-release formulation).
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached about 8 hours post-dose. Absolute bioavailability is approximately 64%. Administration after food may increase absorption.
Metabolism
Extensively metabolized in the liver, primarily via the CYP3A4 enzyme.
Side Effects
Contraindications
- Hypersensitivity to alfuzosin or any component of the formulation.
- Severe hepatic impairment.
- Concomitant administration of other alpha-1 blockers.
- Concomitant use of strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir).
- History of orthostatic hypotension.
Drug Interactions
Antihypertensive Drugs
May enhance the hypotensive effect of alfuzosin.
Other Alpha-1 Blockers
Increased risk of symptomatic hypotension.
PDE5 Inhibitors (e.g., sildenafil, tadalafil)
Concurrent use may lead to symptomatic hypotension, especially within 6 hours of taking alfuzosin.
Strong CYP3A4 Inhibitors (e.g., ketoconazole, ritonavir)
Increase alfuzosin plasma concentrations, increasing risk of adverse effects.
Storage
Store in a cool, dry place, away from light and moisture, below 30°C. Keep out of reach of children.
Overdose
Overdose may result in hypotension. Treatment is symptomatic and supportive. Lay the patient supine and support blood pressure with fluids and vasopressors if necessary. Dialysis is unlikely to be of benefit.
Pregnancy & Lactation
Urocure SR is not indicated for use in women.
Side Effects
Contraindications
- Hypersensitivity to alfuzosin or any component of the formulation.
- Severe hepatic impairment.
- Concomitant administration of other alpha-1 blockers.
- Concomitant use of strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir).
- History of orthostatic hypotension.
Drug Interactions
Antihypertensive Drugs
May enhance the hypotensive effect of alfuzosin.
Other Alpha-1 Blockers
Increased risk of symptomatic hypotension.
PDE5 Inhibitors (e.g., sildenafil, tadalafil)
Concurrent use may lead to symptomatic hypotension, especially within 6 hours of taking alfuzosin.
Strong CYP3A4 Inhibitors (e.g., ketoconazole, ritonavir)
Increase alfuzosin plasma concentrations, increasing risk of adverse effects.
Storage
Store in a cool, dry place, away from light and moisture, below 30°C. Keep out of reach of children.
Overdose
Overdose may result in hypotension. Treatment is symptomatic and supportive. Lay the patient supine and support blood pressure with fluids and vasopressors if necessary. Dialysis is unlikely to be of benefit.
Pregnancy & Lactation
Urocure SR is not indicated for use in women.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of alfuzosin in improving BPH symptoms and urine flow. Key trials showed significant improvements in IPSS (International Prostate Symptom Score) and peak urinary flow rates compared to placebo.
Lab Monitoring
- Regular monitoring of blood pressure, especially at the start of therapy.
- Liver function tests if hepatic impairment is suspected.
Doctor Notes
- Counsel patients on potential for orthostatic hypotension and advise caution with initial dosing and position changes.
- Review concomitant medications for potential interactions, especially strong CYP3A4 inhibitors and other alpha-blockers.
- Advise patients undergoing cataract surgery to inform their ophthalmologist about alfuzosin use to mitigate IFIS risk.
Patient Guidelines
- Take the tablet whole; do not crush, chew, or break.
- Take with food at the same time each day.
- Be aware of potential dizziness or lightheadedness, especially when standing up from a sitting or lying position.
- Avoid driving or operating machinery until you know how this medication affects you.
Missed Dose Advice
If a dose is missed, take the next scheduled dose at the usual time. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness, lightheadedness, or syncope, especially at the start of treatment. Patients should be warned not to drive or operate machinery if these symptoms occur.
Lifestyle Advice
- Maintain a healthy weight.
- Limit alcohol and caffeine intake.
- Avoid long periods of standing.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.