Urokool
Generic Name
Potassium Citrate
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| urokool 1500 mg oral solution | ৳ 200.00 | N/A |
Description
Overview of the medicine
Urokool 1500 mg Oral Solution is used to make the urine less acidic (alkalinize the urine) to help prevent kidney stones, particularly those made of uric acid or calcium oxalate. It works by increasing the pH of urine, which helps to dissolve existing stones and prevent new ones from forming.
Uses & Indications
Dosage
Adults
Typically 10-20 mEq (1080 mg - 2160 mg potassium citrate) three times daily, adjusted to achieve target urinary pH of 6.0-7.0. The 1500 mg strength may be given once, twice, or thrice daily depending on physician's assessment.
Elderly
No specific dose adjustment required, but monitor renal function.
Renal_impairment
Use with caution and monitor serum potassium and renal function. Contraindicated in severe renal impairment.
How to Take
Mix the oral solution with water or juice and drink immediately after meals or within 30 minutes of a meal or bedtime snack to minimize gastrointestinal irritation. Do not chew or suck undiluted solution.
Mechanism of Action
Potassium citrate is metabolized to bicarbonate, which alkalinizes the urine by increasing urinary pH. This increased pH helps to dissolve uric acid stones and inhibits the crystallization of calcium oxalate and uric acid, thereby preventing stone formation.
Pharmacokinetics
Onset
Urinary alkalinization begins within hours of administration.
Excretion
Mainly excreted by the kidneys, with some unchanged citrate and its metabolites in urine.
Half life
Approximately 30-50 minutes (of the citrate ion).
Absorption
Readily absorbed from the gastrointestinal tract.
Metabolism
Citrate is extensively metabolized in the liver to bicarbonate.
Side Effects
Contraindications
- Hyperkalemia (high blood potassium)
- Severe renal impairment
- Untreated Addison's disease
- Acute dehydration
- Adrenal insufficiency
- Conditions predisposing to hyperkalemia (e.g., potassium-sparing diuretics, ACE inhibitors)
- Peptic ulcer disease or other conditions causing delayed gastric emptying or esophageal compression
Drug Interactions
NSAIDs
May reduce the renal excretion of potassium, increasing hyperkalemia risk.
Anticholinergics
May increase risk of GI irritation due to delayed gastric emptying.
ACE inhibitors/ARBs
Increased risk of hyperkalemia.
Potassium-sparing diuretics
Increased risk of severe hyperkalemia.
Storage
Store at room temperature (below 30°C), protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms include hyperkalemia (muscle weakness, irregular heartbeat, fatigue, numbness), metabolic alkalosis. Treatment involves stopping medication, IV calcium gluconate for cardiac effects, insulin/glucose for potassium shift, potassium-exchange resins, and hemodialysis in severe cases.
Pregnancy & Lactation
Category C. Use only if clearly needed and the benefit outweighs the potential risk. Excreted in breast milk, but typically considered compatible with breastfeeding with caution.
Side Effects
Contraindications
- Hyperkalemia (high blood potassium)
- Severe renal impairment
- Untreated Addison's disease
- Acute dehydration
- Adrenal insufficiency
- Conditions predisposing to hyperkalemia (e.g., potassium-sparing diuretics, ACE inhibitors)
- Peptic ulcer disease or other conditions causing delayed gastric emptying or esophageal compression
Drug Interactions
NSAIDs
May reduce the renal excretion of potassium, increasing hyperkalemia risk.
Anticholinergics
May increase risk of GI irritation due to delayed gastric emptying.
ACE inhibitors/ARBs
Increased risk of hyperkalemia.
Potassium-sparing diuretics
Increased risk of severe hyperkalemia.
Storage
Store at room temperature (below 30°C), protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms include hyperkalemia (muscle weakness, irregular heartbeat, fatigue, numbness), metabolic alkalosis. Treatment involves stopping medication, IV calcium gluconate for cardiac effects, insulin/glucose for potassium shift, potassium-exchange resins, and hemodialysis in severe cases.
Pregnancy & Lactation
Category C. Use only if clearly needed and the benefit outweighs the potential risk. Excreted in breast milk, but typically considered compatible with breastfeeding with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date when stored properly.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic
Clinical Trials
Potassium citrate has been widely studied for its efficacy in kidney stone prevention. Numerous randomized controlled trials and meta-analyses support its use.
Lab Monitoring
- Serum electrolytes (especially potassium)
- Renal function (BUN, creatinine)
- Urinary pH (to guide dosing)
- Urine chemistries for stone risk factors (calcium, citrate, uric acid)
Doctor Notes
- Emphasize the importance of adequate fluid intake and dietary modifications.
- Advise patients on proper dilution and administration to minimize GI upset.
- Educate on symptoms of hyperkalemia and when to seek medical attention.
Patient Guidelines
- Take with food to reduce stomach upset.
- Dilute the solution properly before drinking.
- Do not stop taking the medicine without consulting your doctor.
- Report any muscle weakness or tingling sensations immediately.
Missed Dose Advice
If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to catch up.
Driving Precautions
Generally not expected to affect driving ability. However, if side effects like dizziness occur, avoid driving.
Lifestyle Advice
- Maintain adequate fluid intake to help prevent kidney stone formation.
- Limit sodium intake.
- Follow a balanced diet as advised by your doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.