Uromitexan
Generic Name
Mesna
Manufacturer
Baxter
Country
Germany (original), various
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| uromitexan 400 mg injection | ৳ 215.61 | N/A |
Description
Overview of the medicine
Mesna is a detoxifying agent used to prevent hemorrhagic cystitis, a side effect of oxazaphosphorine chemotherapy (e.g., ifosfamide, cyclophosphamide). It works by detoxifying the urotoxic metabolites in the urinary tract.
Uses & Indications
Dosage
Adults
Typically administered at 20% of the ifosfamide/cyclophosphamide dose (on a mg/mg basis) at 0, 4, and 8 hours after chemotherapy start, or as a continuous infusion equivalent to 60% of the chemotherapy dose over 24 hours. Dosage is individualized.
Elderly
No specific dose adjustments needed for elderly patients, use with caution considering overall health and renal function.
Renal_impairment
No specific dose adjustments provided, but caution is advised. Closely monitor for efficacy and toxicity.
How to Take
Administered intravenously as a bolus injection or continuous infusion. Can be diluted in 5% Dextrose in Water or 0.9% Sodium Chloride injection. Always given with oxazaphosphorine chemotherapy.
Mechanism of Action
Mesna contains a free sulfhydryl group that reacts with and inactivates urotoxic metabolites, primarily acrolein, in the urinary tract. Acrolein is a metabolite of ifosfamide and cyclophosphamide responsible for bladder toxicity.
Pharmacokinetics
Onset
Rapid onset after intravenous administration (within minutes).
Excretion
Primarily renal excretion as mesna and dimesna.
Half life
Mesna: approximately 0.36 hours; Dimesna (mesna disulfide): approximately 1.17 hours.
Absorption
Administered intravenously, mesna is rapidly absorbed into the plasma. Oral bioavailability is poor.
Metabolism
Rapidly oxidized to dimesna (mesna disulfide), which is then reduced back to mesna. Minor metabolism through sulfhydryl-alkylation.
Side Effects
Contraindications
- •Hypersensitivity to mesna or any thiol-containing compounds.
- •Known allergic reactions to mesna.
Drug Interactions
Cisplatin
Mesna may theoretically reduce the efficacy of cisplatin if directly mixed or given concomitantly, though clinical significance is unclear. Administer separately if possible.
Storage
Store below 25°C or at room temperature (15-30°C). Protect from light. Do not freeze. Diluted solutions should be used within 24 hours.
Overdose
There is no specific antidote for mesna overdose. Management is supportive and symptomatic. Hemodialysis may be considered in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed and the potential benefit outweighs the potential risk to the fetus. It is unknown if Mesna is excreted in human milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, check manufacturer's label for exact expiry.
Availability
Available in hospitals and specialized pharmacies
Approval Status
Approved by major regulatory bodies globally
Patent Status
Off-patent
WHO Essential Medicine
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Global Brand Names
International brand names for this medicine
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