Utracet
Generic Name
Tramadol Hydrochloride + Paracetamol
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| utracet 325 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
A combination pain reliever containing Tramadol and Paracetamol, used for moderate to severe pain.
Uses & Indications
Dosage
Adults
Typically 1-2 tablets every 4-6 hours as needed, not exceeding 8 tablets per day.
Elderly
Lower doses may be required, closely monitor for adverse effects.
Renal_impairment
Adjust dose and increase dosing interval (e.g., every 12 hours) for patients with creatinine clearance <30 mL/min.
How to Take
Oral. Can be taken with or without food. Swallow whole, do not crush or chew.
Mechanism of Action
Tramadol acts centrally by binding to mu-opioid receptors and inhibiting reuptake of norepinephrine and serotonin. Paracetamol inhibits prostaglandin synthesis in the central nervous system.
Pharmacokinetics
Onset
Within 1 hour for pain relief
Excretion
Primarily via kidneys (urine)
Half life
Tramadol: ~6-7 hours; Paracetamol: ~2-3 hours
Absorption
Both Tramadol and Paracetamol are well absorbed orally. Tramadol's bioavailability is about 75%. Paracetamol's absorption is rapid and almost complete.
Metabolism
Both are metabolized in the liver. Tramadol undergoes O-demethylation (to active metabolite M1) and N-demethylation, followed by glucuronidation. Paracetamol undergoes glucuronidation and sulfation.
Side Effects
Contraindications
- Hypersensitivity to tramadol, paracetamol, or any component
- Acute alcohol, hypnotics, analgesics, opioids, psychotropic drugs intoxication
- Severe respiratory depression
- Concurrent use with MAOIs
- Uncontrolled epilepsy
Drug Interactions
MAOIs
Risk of serotonin syndrome and opioid toxicity.
Warfarin
Increased INR (International Normalized Ratio) and bleeding risk with Paracetamol.
SSRIs/SNRIs
Increased risk of serotonin syndrome.
Carbamazepine
Decreased tramadol efficacy.
CNS Depressants (alcohol, sedatives, hypnotics)
Increased risk of respiratory depression and profound sedation.
Storage
Store below 30°C, in a cool and dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include respiratory depression, seizures, coma (tramadol) and hepatic necrosis (paracetamol). Management involves supportive care, naloxone for opioid effects, and N-acetylcysteine for paracetamol toxicity.
Pregnancy & Lactation
Not recommended during pregnancy unless clearly necessary. Avoid during lactation as both components pass into breast milk.
Side Effects
Contraindications
- Hypersensitivity to tramadol, paracetamol, or any component
- Acute alcohol, hypnotics, analgesics, opioids, psychotropic drugs intoxication
- Severe respiratory depression
- Concurrent use with MAOIs
- Uncontrolled epilepsy
Drug Interactions
MAOIs
Risk of serotonin syndrome and opioid toxicity.
Warfarin
Increased INR (International Normalized Ratio) and bleeding risk with Paracetamol.
SSRIs/SNRIs
Increased risk of serotonin syndrome.
Carbamazepine
Decreased tramadol efficacy.
CNS Depressants (alcohol, sedatives, hypnotics)
Increased risk of respiratory depression and profound sedation.
Storage
Store below 30°C, in a cool and dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include respiratory depression, seizures, coma (tramadol) and hepatic necrosis (paracetamol). Management involves supportive care, naloxone for opioid effects, and N-acetylcysteine for paracetamol toxicity.
Pregnancy & Lactation
Not recommended during pregnancy unless clearly necessary. Avoid during lactation as both components pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Expired for generic components
Clinical Trials
Extensive clinical trials have established the efficacy and safety of Tramadol/Paracetamol combination for moderate to severe pain.
Lab Monitoring
- Liver function tests (with long-term use or high doses of paracetamol)
- Renal function tests
Doctor Notes
- Assess patient's pain level and history of substance abuse before prescribing.
- Educate patients on proper use and risks of opioid components.
- Monitor for signs of respiratory depression, especially in elderly or patients with pre-existing respiratory conditions.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid alcohol while taking this medicine.
- Do not stop suddenly if used long-term without consulting a doctor.
- Report any unusual side effects.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not take extra medicine to make up the missed dose.
Driving Precautions
May cause drowsiness or dizziness; avoid driving or operating machinery until effects are known.
Lifestyle Advice
- Stay hydrated to prevent constipation.
- Avoid operating heavy machinery or driving until you know how the medicine affects you.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.