Uzu
Generic Name
Cetirizine Hydrochloride
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| uzu 10 mg syrup | ৳ 30.00 | N/A |
Description
Overview of the medicine
Uzu 10 mg Syrup contains Cetirizine Hydrochloride, a potent second-generation antihistamine, used for the relief of symptoms associated with allergic conditions such as hay fever, chronic urticaria, and allergic rhinitis.
Uses & Indications
Dosage
Adults
10 mg (5 ml) once daily, or 5 mg (2.5 ml) twice daily. Maximum 10 mg/day.
Elderly
5 mg (2.5 ml) once daily. Dosage adjustment may be required based on renal function.
Renal_impairment
Creatinine clearance 31-60 ml/min: 5 mg (2.5 ml) once daily. Creatinine clearance 11-30 ml/min: 5 mg (2.5 ml) every other day. Less than 10 ml/min: Contraindicated.
How to Take
Oral administration. May be taken with or without food. Use a measuring spoon or oral syringe for accurate dosing.
Mechanism of Action
Cetirizine selectively inhibits peripheral H1 receptors, thereby preventing the histamine-induced effects such as vasodilation, increased capillary permeability, and pruritus. It does not readily cross the blood-brain barrier, leading to fewer sedative effects.
Pharmacokinetics
Onset
20-60 minutes
Excretion
Excreted primarily via the kidneys (about 60% unchanged drug in urine).
Half life
Approximately 8-12 hours in adults
Absorption
Rapidly and extensively absorbed after oral administration. Peak plasma concentrations are achieved within 1 hour.
Metabolism
Minimal hepatic metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to cetirizine, hydroxyzine, or any piperazine derivatives
- Severe renal impairment (creatinine clearance less than 10 ml/min)
Drug Interactions
Ritonavir
Increases plasma concentration of cetirizine.
CNS depressants (e.g., alcohol, sedatives)
May enhance CNS depressant effects, leading to increased drowsiness.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, tachycardia, tremor, and urinary retention. Treatment is symptomatic and supportive; no specific antidote. Gastric lavage may be considered soon after ingestion.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk, so caution is advised for nursing mothers. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available (Patent expired)
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of cetirizine for allergic conditions in various age groups.
Lab Monitoring
- No routine laboratory monitoring required. Liver and renal function tests may be considered in patients with pre-existing conditions or long-term use.
Doctor Notes
- Advise patients regarding potential drowsiness, especially when starting treatment.
- Consider renal function when prescribing to elderly patients or those with kidney impairment.
- Emphasize the importance of consistent daily dosing for optimal effect.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid driving or operating heavy machinery if drowsiness occurs.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause drowsiness or dizziness. Patients should be warned not to drive or operate hazardous machinery until they know how they react to the medication.
Lifestyle Advice
- Avoid known allergens to reduce symptoms.
- Maintain good hydration.
- Consider using a humidifier for nasal comfort.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.