Vancin
Generic Name
vancin-500-mg-injection
Manufacturer
Example Pharma Ltd.
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vancin 500 mg injection | ৳ 300.00 | N/A |
Description
Overview of the medicine
Vancomycin is a glycopeptide antibiotic used to treat serious bacterial infections, especially those caused by Gram-positive bacteria resistant to other antibiotics. It is administered intravenously for systemic infections.
Uses & Indications
Dosage
Adults
Typical dose is 15-20 mg/kg intravenously every 8-12 hours, not exceeding 2 g per dose or 3-4 g daily. Infusion must be over at least 60 minutes.
Elderly
Dose adjustments may be necessary based on age-related decline in renal function. Monitor serum levels closely.
Renal_impairment
Significant dose reduction and/or increased dosing interval required. Dosing must be guided by therapeutic drug monitoring (serum trough levels) and renal function tests (creatinine clearance).
How to Take
Vancin 500 mg injection is reconstituted and administered as a slow intravenous infusion over at least 60 minutes to minimize the risk of infusion-related reactions (e.g., Red Man Syndrome). It should not be given as a rapid bolus injection.
Mechanism of Action
Vancomycin inhibits bacterial cell wall synthesis by binding to the D-Ala-D-Ala terminus of nascent peptidoglycan chains, leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
Rapid, within minutes of intravenous infusion.
Excretion
Mainly via renal glomerular filtration. Small amounts are excreted in bile and feces.
Half life
Approximately 4 to 6 hours in adults with normal renal function; significantly prolonged in renal impairment.
Absorption
Poorly absorbed orally; systemic infections require intravenous administration. Peak plasma concentrations are achieved at the end of infusion.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to vancomycin or any component of the formulation.
- Previous severe allergic reaction to vancomycin.
Drug Interactions
Loop diuretics (e.g., furosemide)
May increase the risk of ototoxicity, especially with rapid intravenous administration.
Aminoglycosides (e.g., gentamicin, amikacin)
Increased risk of nephrotoxicity and ototoxicity.
Amphotericin B, Cisplatin, Cyclosporine, NSAIDs
Increased risk of nephrotoxicity.
Neuromuscular blockers (e.g., succinylcholine, rocuronium)
May potentiate and prolong the effects of neuromuscular blockade.
Storage
Store unopened vials at controlled room temperature (20-25°C), protected from light. Reconstituted solutions have specific storage requirements (e.g., refrigerate for a certain period) as per manufacturer's instructions.
Overdose
Management of vancomycin overdose is primarily supportive. Hemodialysis or hemofiltration may be useful in removing vancomycin from the blood, particularly in patients with severe renal impairment.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if clearly needed and the potential benefits outweigh the potential risks to the fetus. Vancomycin is excreted in breast milk; caution should be exercised when administering to a nursing mother, and infants should be monitored for adverse effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months when stored unopened. Refer to the product label for the exact expiry date and reconstituted solution stability.
Availability
Hospitals, Clinics, Retail Pharmacies
Approval Status
Approved by major regulatory bodies
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Vancomycin has been extensively studied in numerous clinical trials since its introduction, establishing its efficacy and safety profile across a wide range of serious Gram-positive infections. Ongoing research focuses on optimizing dosing strategies and monitoring for resistance.
Lab Monitoring
- Serum vancomycin trough levels (essential for therapeutic drug monitoring and dose adjustment)
- Renal function tests (blood urea nitrogen (BUN), serum creatinine, creatinine clearance) prior to and during therapy
- Complete blood count (CBC) to monitor for neutropenia or thrombocytopenia
- Audiograms (hearing tests) if there is a concern for ototoxicity or in patients at higher risk
Doctor Notes
- Therapeutic drug monitoring (TDM) of vancomycin trough levels is essential to achieve optimal efficacy and minimize toxicity. Target troughs are generally 10-15 mcg/mL for uncomplicated infections and 15-20 mcg/mL for serious infections (e.g., endocarditis, osteomyelitis, MRSA pneumonia).
- Dose adjustment is critical in patients with renal impairment. Consult institutional guidelines or nephrology for complex cases. Avoid co-administration with other nephrotoxic agents whenever possible.
- Infusion-related reactions (Red Man Syndrome) can be mitigated by slow infusion rates (over ≥60 minutes, preferably ≥90-120 minutes for higher doses) and pre-medication with antihistamines if necessary.
Patient Guidelines
- Report any signs of an allergic reaction (e.g., rash, swelling, difficulty breathing) immediately.
- Inform healthcare providers if you experience ringing in your ears, hearing changes, or dizziness.
- Notify if you notice decreased urine output or swelling in your ankles/feet, as these can be signs of kidney problems.
- Ensure you receive your infusion slowly over the recommended time to avoid side effects like 'Red Man Syndrome'.
Missed Dose Advice
If a dose is missed, it should be administered as soon as possible, unless it is almost time for the next scheduled dose. Do not double the dose. Consult your physician or healthcare provider for guidance.
Driving Precautions
Vancin may cause dizziness or changes in hearing in some individuals. If you experience these side effects, avoid driving or operating machinery until you know how the medication affects you.
Lifestyle Advice
- Maintain good hydration during therapy to support kidney function.
- Avoid concomitant use of other drugs that can harm the kidneys or ears without consulting your doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.