Vasopressin
Generic Name
vasopressin-20-unit-injection
Manufacturer
Various Generic Manufacturers
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vasopressin 20 unit injection | ৳ 700.00 | N/A |
Description
Overview of the medicine
Vasopressin is a synthetic polypeptide hormone used for its antidiuretic and vasopressor effects. It is primarily used to treat diabetes insipidus and certain forms of vasodilatory shock.
Uses & Indications
Dosage
Adults
Diabetes Insipidus: 5-10 units intramuscularly or subcutaneously 2-3 times daily. Septic Shock: 0.01-0.04 units/minute continuous IV infusion. Esophageal Varices: 0.2-0.4 units/minute IV infusion.
Elderly
Use with caution due to increased risk of adverse cardiovascular events and fluid/electrolyte disturbances. Dosage may need to be adjusted based on individual response and comorbidities.
Renal_impairment
No specific dose adjustment guidelines due to rapid metabolism, but monitor fluid and electrolytes closely.
How to Take
Administered via intravenous (IV) infusion, intramuscular (IM) or subcutaneous (SC) injection. IV administration for acute conditions, IM/SC for diabetes insipidus.
Mechanism of Action
Vasopressin acts on V1 receptors in vascular smooth muscle, causing vasoconstriction, and on V2 receptors in the renal collecting ducts, increasing water reabsorption. It also stimulates release of Factor VIII and von Willebrand factor.
Pharmacokinetics
Onset
Rapid (within minutes) after IV administration.
Excretion
Renal excretion of inactive metabolites; small amount excreted unchanged in urine.
Half life
10-20 minutes.
Absorption
Rapidly absorbed after intramuscular/subcutaneous administration; IV administration provides immediate systemic availability.
Metabolism
Primarily hepatic and renal metabolism by peptidases.
Side Effects
Contraindications
- •Hypersensitivity to vasopressin or any component of the formulation.
- •Chronic nephritis with nitrogen retention (relative contraindication).
Drug Interactions
Catecholamines
May potentiate the pressor effect of vasopressin.
Loop Diuretics
May potentiate antidiuretic effects and risk of hyponatremia.
Lithium, Demeclocycline, Norepinephrine
May reduce the antidiuretic effect of vasopressin.
Carbamazepine, Chlorpropamide, Clofibrate
May potentiate the antidiuretic effect of vasopressin.
Storage
Store refrigerated at 2-8°C (36-46°F). Protect from light. Do not freeze.
Overdose
Symptoms of overdose include severe fluid retention, hyponatremia, and excessive vasoconstriction leading to pallor, abdominal cramps, and nausea. Management involves discontinuing vasopressin, fluid restriction, and possibly diuretics.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed and the potential benefits outweigh the risks. Excretion into breast milk is unknown; caution advised for breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, consult specific product labeling.
Availability
Available in hospitals and pharmacies
Approval Status
Approved by major regulatory bodies globally
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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