Vasopressin
Generic Name
vasopressin-20-unit-injection
Manufacturer
Various Generic Manufacturers
Country
Global
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vasopressin 20 unit injection | ৳ 700.00 | N/A |
Description
Overview of the medicine
Vasopressin is a synthetic polypeptide hormone used for its antidiuretic and vasopressor effects. It is primarily used to treat diabetes insipidus and certain forms of vasodilatory shock.
Uses & Indications
Dosage
Adults
Diabetes Insipidus: 5-10 units intramuscularly or subcutaneously 2-3 times daily. Septic Shock: 0.01-0.04 units/minute continuous IV infusion. Esophageal Varices: 0.2-0.4 units/minute IV infusion.
Elderly
Use with caution due to increased risk of adverse cardiovascular events and fluid/electrolyte disturbances. Dosage may need to be adjusted based on individual response and comorbidities.
Renal_impairment
No specific dose adjustment guidelines due to rapid metabolism, but monitor fluid and electrolytes closely.
How to Take
Administered via intravenous (IV) infusion, intramuscular (IM) or subcutaneous (SC) injection. IV administration for acute conditions, IM/SC for diabetes insipidus.
Mechanism of Action
Vasopressin acts on V1 receptors in vascular smooth muscle, causing vasoconstriction, and on V2 receptors in the renal collecting ducts, increasing water reabsorption. It also stimulates release of Factor VIII and von Willebrand factor.
Pharmacokinetics
Onset
Rapid (within minutes) after IV administration.
Excretion
Renal excretion of inactive metabolites; small amount excreted unchanged in urine.
Half life
10-20 minutes.
Absorption
Rapidly absorbed after intramuscular/subcutaneous administration; IV administration provides immediate systemic availability.
Metabolism
Primarily hepatic and renal metabolism by peptidases.
Side Effects
Contraindications
- Hypersensitivity to vasopressin or any component of the formulation.
- Chronic nephritis with nitrogen retention (relative contraindication).
Drug Interactions
Catecholamines
May potentiate the pressor effect of vasopressin.
Loop Diuretics
May potentiate antidiuretic effects and risk of hyponatremia.
Lithium, Demeclocycline, Norepinephrine
May reduce the antidiuretic effect of vasopressin.
Carbamazepine, Chlorpropamide, Clofibrate
May potentiate the antidiuretic effect of vasopressin.
Storage
Store refrigerated at 2-8°C (36-46°F). Protect from light. Do not freeze.
Overdose
Symptoms of overdose include severe fluid retention, hyponatremia, and excessive vasoconstriction leading to pallor, abdominal cramps, and nausea. Management involves discontinuing vasopressin, fluid restriction, and possibly diuretics.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed and the potential benefits outweigh the risks. Excretion into breast milk is unknown; caution advised for breastfeeding mothers.
Side Effects
Contraindications
- Hypersensitivity to vasopressin or any component of the formulation.
- Chronic nephritis with nitrogen retention (relative contraindication).
Drug Interactions
Catecholamines
May potentiate the pressor effect of vasopressin.
Loop Diuretics
May potentiate antidiuretic effects and risk of hyponatremia.
Lithium, Demeclocycline, Norepinephrine
May reduce the antidiuretic effect of vasopressin.
Carbamazepine, Chlorpropamide, Clofibrate
May potentiate the antidiuretic effect of vasopressin.
Storage
Store refrigerated at 2-8°C (36-46°F). Protect from light. Do not freeze.
Overdose
Symptoms of overdose include severe fluid retention, hyponatremia, and excessive vasoconstriction leading to pallor, abdominal cramps, and nausea. Management involves discontinuing vasopressin, fluid restriction, and possibly diuretics.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed and the potential benefits outweigh the risks. Excretion into breast milk is unknown; caution advised for breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, consult specific product labeling.
Availability
Available in hospitals and pharmacies
Approval Status
Approved by major regulatory bodies globally
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Vasopressin has been extensively studied for decades, particularly in critical care settings for septic shock and in the management of diabetes insipidus and gastrointestinal hemorrhage. Current research focuses on its role in various shock states and new formulations.
Lab Monitoring
- Serum electrolytes (especially sodium and potassium)
- Urine output and specific gravity
- Blood pressure and heart rate
- ECG monitoring (in high-risk patients)
- Fluid balance
Doctor Notes
- Closely monitor fluid balance, serum electrolytes (especially sodium), blood pressure, and cardiac status.
- Administer via central venous line if possible for continuous infusion in shock.
- Exercise caution in patients with coronary artery disease, asthma, or epilepsy.
Patient Guidelines
- This medication is usually administered by a healthcare professional in a hospital setting.
- Report any unusual symptoms or discomfort immediately.
- Understand the purpose of the injection for your condition.
Missed Dose Advice
As vasopressin is typically administered in acute, hospital settings, missed doses are uncommon. If used for chronic conditions like diabetes insipidus, administer the missed dose as soon as remembered unless it's close to the next dose. Do not double dose. Contact your doctor for advice.
Driving Precautions
Vasopressin is typically used in acute, critical care settings where driving is not applicable.
Lifestyle Advice
- For diabetes insipidus, maintain adequate fluid intake as advised by your doctor.
- Follow all medical advice regarding your underlying condition.
- Regular follow-ups are crucial.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.