Vasoproct
Generic Name
Diosmin
Manufacturer
MediLife Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vasoproct 500 mg capsule | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Vasoproct 500 mg Capsule is a venotonic and vasoprotective medication used to treat symptoms associated with venous insufficiency and acute hemorrhoidal attacks.
Uses & Indications
Dosage
Adults
For chronic venous insufficiency: 1 capsule (500 mg) daily. For acute hemorrhoidal attacks: 3 capsules (1500 mg) twice daily for 4 days, then 2 capsules (1000 mg) twice daily for 3 days.
Elderly
No specific dose adjustment is required, but caution is advised in elderly patients with comorbidities.
Renal_impairment
Use with caution in severe renal impairment. No specific guidelines, but consider dose reduction if adverse effects occur.
How to Take
Swallow the capsule whole with water, preferably with meals to minimize gastrointestinal discomfort.
Mechanism of Action
Vasoproct acts by increasing venous tone and decreasing capillary permeability, leading to improved venous return and reduced inflammation. It enhances lymphatic drainage and reduces leukocyte adhesion to the endothelium, thereby alleviating symptoms of venous disease.
Pharmacokinetics
Onset
Symptomatic relief usually observed within hours to days for acute conditions.
Excretion
Primarily via urine (approx. 80%) and feces (approx. 20%) as metabolites.
Half life
Approximately 11-14 hours (for active metabolites).
Absorption
Rapidly absorbed after oral administration. Extensively metabolized to phenolic acids.
Metabolism
Extensively metabolized in the intestine by intestinal flora and then in the liver to phenolic acids, which are then conjugated.
Side Effects
Contraindications
- Hypersensitivity to Diosmin or any component of the formulation.
- Lactation (for high doses in acute conditions due to insufficient data).
Drug Interactions
Anticoagulants (e.g., Warfarin)
While not definitively proven, some studies suggest a potential for Diosmin to slightly enhance the effect of anticoagulants. Monitor INR if co-administered.
No other significant drug interactions are generally reported.
No other significant drug interactions are generally reported.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and may include gastrointestinal disturbances (nausea, diarrhea) or headache. Treatment is symptomatic and supportive. Gastric lavage may be considered in recent, large overdoses.
Pregnancy & Lactation
Pregnancy: Limited human data suggest no adverse effects. Use only if clearly needed after consulting a physician. Lactation: Avoid use during breastfeeding, especially for acute conditions with high doses, as data on excretion into breast milk is insufficient.
Side Effects
Contraindications
- Hypersensitivity to Diosmin or any component of the formulation.
- Lactation (for high doses in acute conditions due to insufficient data).
Drug Interactions
Anticoagulants (e.g., Warfarin)
While not definitively proven, some studies suggest a potential for Diosmin to slightly enhance the effect of anticoagulants. Monitor INR if co-administered.
No other significant drug interactions are generally reported.
No other significant drug interactions are generally reported.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and may include gastrointestinal disturbances (nausea, diarrhea) or headache. Treatment is symptomatic and supportive. Gastric lavage may be considered in recent, large overdoses.
Pregnancy & Lactation
Pregnancy: Limited human data suggest no adverse effects. Use only if clearly needed after consulting a physician. Lactation: Avoid use during breastfeeding, especially for acute conditions with high doses, as data on excretion into breast milk is insufficient.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Diosmin in treating chronic venous insufficiency and acute hemorrhoidal disease.
Lab Monitoring
- No specific routine lab monitoring is required for Vasoproct.
- If co-administered with anticoagulants, monitor INR regularly.
Doctor Notes
- Advise patients on lifestyle modifications (e.g., exercise, diet, avoiding prolonged standing/sitting) alongside medication for optimal results.
- For acute hemorrhoids, high doses are used for short durations, followed by maintenance or lower doses. Emphasize compliance.
Patient Guidelines
- Take the medicine regularly as prescribed by your doctor.
- For hemorrhoids, ensure adequate fiber intake and hydration.
- Report any unusual side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Generally, Vasoproct does not affect the ability to drive or operate machinery. However, if you experience dizziness or headache, avoid such activities.
Lifestyle Advice
- Avoid prolonged standing or sitting to improve venous circulation.
- Engage in regular exercise, maintain a healthy weight, and elevate legs when resting.
- Avoid wearing tight clothing.
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