Veelac
Generic Name
veelac-335-gm-oral-solution
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| veelac 335 gm oral solution | ৳ 144.00 | N/A |
Description
Overview of the medicine
Veelac 335 gm Oral Solution is a synthetic disaccharide used as an osmotic laxative to treat chronic constipation and hepatic encephalopathy. It helps soften stools and promote bowel movements by drawing water into the colon. In hepatic encephalopathy, it reduces blood ammonia levels.
Uses & Indications
Dosage
Adults
For constipation: Initially 15-45 mL daily; maintenance 15-30 mL daily. For hepatic encephalopathy: Initially 30-45 mL 3-4 times daily, adjusted to produce 2-3 soft stools per day.
Elderly
Same as adults, but may require lower initial doses and slower titration. Use with caution in patients with underlying comorbidities.
Renal_impairment
No dose adjustment required as it is minimally absorbed and renally excreted.
How to Take
Can be taken orally, either undiluted or diluted with water, fruit juice, or milk. For constipation, usually taken as a single daily dose or divided into two doses. For hepatic encephalopathy, doses are typically divided throughout the day.
Mechanism of Action
Lactulose is a disaccharide that is not absorbed in the small intestine. It passes unchanged into the large intestine, where it is metabolized by colonic bacteria into low molecular weight organic acids (lactic acid, acetic acid). These acids lower the pH of the colonic contents and increase the osmotic pressure, leading to an influx of water into the colon. This softens the stool and stimulates peristalsis, promoting defecation. In hepatic encephalopathy, the acidification of the colonic contents traps ammonia as ammonium ions, preventing its absorption into the bloodstream and facilitating its excretion.
Pharmacokinetics
Onset
Constipation: 24-48 hours; Hepatic Encephalopathy: 24 hours to 3 days.
Excretion
Unabsorbed lactulose and its metabolites are excreted primarily in feces. Absorbed portion (minimal) is excreted in urine.
Half life
Not directly applicable as it is minimally absorbed; if absorbed, short (approx. 2 hours).
Absorption
Minimally absorbed (less than 3%) orally.
Metabolism
Metabolized by colonic bacteria into lactic acid and acetic acid.
Side Effects
Contraindications
- Galactosemia
- Intestinal obstruction
- Hypersensitivity to lactulose or any components of the solution
- Patients on a low galactose diet
Drug Interactions
Antacids
May neutralize the acidifying effect of lactulose in the colon, potentially reducing its efficacy.
Other laxatives
Concurrent use may make it difficult to assess the proper lactulose dosage for hepatic encephalopathy.
Non-absorbable antacids
Can reduce the efficacy of lactulose, especially in hepatic encephalopathy management.
Storage
Store below 30°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms include abdominal pain, severe diarrhea, and electrolyte disturbances (e.g., hypokalemia, hyponatremia). Treatment is symptomatic and supportive, including correction of fluid and electrolyte imbalances.
Pregnancy & Lactation
Generally considered safe during pregnancy and lactation as it is minimally absorbed systemically. However, consult a doctor before use.
Side Effects
Contraindications
- Galactosemia
- Intestinal obstruction
- Hypersensitivity to lactulose or any components of the solution
- Patients on a low galactose diet
Drug Interactions
Antacids
May neutralize the acidifying effect of lactulose in the colon, potentially reducing its efficacy.
Other laxatives
Concurrent use may make it difficult to assess the proper lactulose dosage for hepatic encephalopathy.
Non-absorbable antacids
Can reduce the efficacy of lactulose, especially in hepatic encephalopathy management.
Storage
Store below 30°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms include abdominal pain, severe diarrhea, and electrolyte disturbances (e.g., hypokalemia, hyponatremia). Treatment is symptomatic and supportive, including correction of fluid and electrolyte imbalances.
Pregnancy & Lactation
Generally considered safe during pregnancy and lactation as it is minimally absorbed systemically. However, consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date when stored under recommended conditions.
Availability
Pharmacies nationwide in Bangladesh
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of lactulose for its approved indications, including chronic constipation and hepatic encephalopathy.
Lab Monitoring
- Electrolyte levels (especially potassium and sodium, with prolonged use or in hepatic encephalopathy patients)
- Fluid balance monitoring
Doctor Notes
- Educate patients on the importance of adequate hydration and dietary fiber intake to complement lactulose therapy.
- Monitor electrolyte levels regularly, particularly in patients with hepatic encephalopathy or those on prolonged high-dose therapy.
- Advise patients that the onset of action for constipation may take 1-2 days, and initial flatulence is common and usually transient.
Patient Guidelines
- Drink plenty of fluids (6-8 glasses of water) daily while taking this medication to help with its effect and prevent dehydration.
- Do not use for more than one week without consulting a doctor, unless advised for chronic conditions.
- Report severe diarrhea, abdominal pain, or unusual weakness to your doctor.
- Diabetic patients should use with caution and monitor blood sugar levels, as Veelac contains sugars.
- Do not stop taking the medicine suddenly in hepatic encephalopathy without consulting your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Veelac is not known to affect the ability to drive or operate machinery. However, if you experience dizziness or severe abdominal discomfort, avoid such activities.
Lifestyle Advice
- Increase dietary fiber intake from fruits, vegetables, and whole grains.
- Maintain adequate hydration by drinking water regularly.
- Engage in regular physical activity to promote bowel regularity.
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Global Brand Names
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