Venopex
Generic Name
Venofibrin 100 mg Injection
Manufacturer
Medicure Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| venopex 100 mg injection | ৳ 325.00 | N/A |
Description
Overview of the medicine
Venopex 100 mg Injection contains Venofibrin, a synthetic venotonic agent used to improve venous tone, reduce capillary permeability, and improve lymphatic drainage. It is primarily indicated for conditions related to venous insufficiency.
Uses & Indications
Dosage
Adults
For Chronic Venous Insufficiency: 100 mg once daily by slow intravenous injection or infusion. For Acute Hemorrhoidal Crises: 100 mg two to three times daily for a short period (e.g., 3-5 days), then reduce to once daily.
Elderly
No specific dose adjustment is generally required, but caution is advised in elderly patients with significant comorbidities.
Renal_impairment
No specific dose adjustment for mild to moderate renal impairment. Use with caution in severe renal impairment, monitor for adverse effects.
How to Take
Venopex 100 mg Injection should be administered by slow intravenous injection over 2-3 minutes or diluted in an appropriate intravenous solution (e.g., normal saline or 5% dextrose) and administered as an infusion. Do not administer intramuscularly or subcutaneously. Ensure proper aseptic technique.
Mechanism of Action
Venofibrin acts by increasing venous tone, leading to improved venous return and reduced venous stasis. It also reduces capillary permeability and fragility, thereby decreasing edema. Additionally, it enhances lymphatic drainage, contributing to its overall vasoprotective effects.
Pharmacokinetics
Onset
Within minutes after intravenous administration.
Excretion
Mainly through renal excretion (urine), with a minor portion excreted via bile.
Half life
Approximately 2-4 hours.
Absorption
Rapid and complete absorption after intravenous administration.
Metabolism
Primarily hepatic metabolism into inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Venofibrin or any component of the injection.
- Severe arterial insufficiency.
Drug Interactions
Corticosteroids
May enhance the vasoprotective effects; no significant adverse interactions reported.
Anticoagulants/Antiplatelets
Caution is advised when co-administered with anticoagulants or antiplatelet agents due to a theoretical risk of increased bleeding, though clinical significance is generally low.
Storage
Store below 30°C. Protect from light. Do not freeze.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote for Venofibrin. Monitor vital signs and manage any adverse reactions.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown if Venofibrin is excreted in human milk; caution should be exercised when administered to a nursing mother. Consult a physician.
Side Effects
Contraindications
- Hypersensitivity to Venofibrin or any component of the injection.
- Severe arterial insufficiency.
Drug Interactions
Corticosteroids
May enhance the vasoprotective effects; no significant adverse interactions reported.
Anticoagulants/Antiplatelets
Caution is advised when co-administered with anticoagulants or antiplatelet agents due to a theoretical risk of increased bleeding, though clinical significance is generally low.
Storage
Store below 30°C. Protect from light. Do not freeze.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote for Venofibrin. Monitor vital signs and manage any adverse reactions.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown if Venofibrin is excreted in human milk; caution should be exercised when administered to a nursing mother. Consult a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Hospitals, Clinics, Pharmacies
Approval Status
Approved by health authorities
Patent Status
Patent Pending
Clinical Trials
Clinical trials have demonstrated the efficacy of Venofibrin in reducing symptoms of chronic venous insufficiency and acute hemorrhoidal crises, showing significant improvement in venous tone and reduction in edema compared to placebo.
Lab Monitoring
- Not routinely required. In patients with severe renal or hepatic impairment, monitoring of kidney and liver function tests may be advisable.
Doctor Notes
- Assess for history of hypersensitivity before administration.
- Administer slowly to minimize injection site reactions.
- Advise patients on lifestyle modifications to complement therapy.
Patient Guidelines
- Report any unusual symptoms or side effects immediately to your healthcare provider.
- Ensure proper hydration during treatment.
- Follow your doctor's instructions regarding administration and dosage.
Missed Dose Advice
If a dose is missed, it should be administered as soon as possible. However, if it is almost time for the next scheduled dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Venopex is generally not expected to impair the ability to drive or operate machinery. However, if you experience dizziness or fatigue, avoid such activities.
Lifestyle Advice
- Elevate legs when resting.
- Regular physical activity (e.g., walking) is encouraged.
- Avoid prolonged standing or sitting.
- Wear compression stockings as advised by your doctor.
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Global Brand Names
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