Venpa
Generic Name
Venlafaxine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| venpa 25 mg capsule | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Venlafaxine is an antidepressant used to treat major depressive disorder, generalized anxiety disorder, panic disorder, and social anxiety disorder. It belongs to the class of serotonin-noradrenaline reuptake inhibitors (SNRIs).
Uses & Indications
Dosage
Adults
Initial dose typically 75 mg/day (for IR) in 2-3 divided doses, can be increased up to 375 mg/day if needed. 25 mg is usually for titration or specific cases.
Elderly
Similar to adults, but with caution; lower initial doses may be considered, and careful monitoring is recommended.
Renal_impairment
Reduce total daily dose by 25-50% depending on creatinine clearance.
How to Take
Take orally, with food, usually twice or thrice daily for IR capsules. Swallow whole; do not crush, chew, or open the capsule.
Mechanism of Action
Venlafaxine selectively inhibits the reuptake of serotonin and norepinephrine, and weakly inhibits the reuptake of dopamine in the central nervous system. This increases the concentration of these neurotransmitters in the synaptic cleft, thereby enhancing their effects.
Pharmacokinetics
Onset
Typically 1-2 weeks for initial antidepressant effects; full effect up to 4-6 weeks.
Excretion
Primarily via urine as metabolites (87%), with a small amount of unchanged drug (5%).
Half life
Venlafaxine: 5 ± 2 hours; O-desmethylvenlafaxine (ODV, active metabolite): 11 ± 2 hours.
Absorption
Well absorbed after oral administration, bioavailability approximately 45%. Peak plasma concentrations are reached in approximately 2 hours for immediate-release (IR) formulations.
Metabolism
Extensively metabolized in the liver, primarily by CYP2D6 to its active metabolite O-desmethylvenlafaxine (ODV).
Side Effects
Contraindications
- Hypersensitivity to venlafaxine or any component of the formulation.
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOIs.
Drug Interactions
MAOIs
Serotonin syndrome risk.
Warfarin
Increased risk of bleeding.
CYP2D6 inhibitors
Increased venlafaxine and ODV levels.
SSRIs, SNRIs, Triptans, Fentanyl, Lithium, Tramadol
Increased risk of serotonin syndrome.
Storage
Store below 30°C, protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include somnolence, mild tachycardia, mydriasis, seizures, vomiting, and ECG changes. Management is supportive and symptomatic, with maintenance of airway, breathing, and circulation.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Neonatal withdrawal symptoms have been reported. Not recommended during breastfeeding due to excretion into breast milk and potential adverse effects on the infant.
Side Effects
Contraindications
- Hypersensitivity to venlafaxine or any component of the formulation.
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOIs.
Drug Interactions
MAOIs
Serotonin syndrome risk.
Warfarin
Increased risk of bleeding.
CYP2D6 inhibitors
Increased venlafaxine and ODV levels.
SSRIs, SNRIs, Triptans, Fentanyl, Lithium, Tramadol
Increased risk of serotonin syndrome.
Storage
Store below 30°C, protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include somnolence, mild tachycardia, mydriasis, seizures, vomiting, and ECG changes. Management is supportive and symptomatic, with maintenance of airway, breathing, and circulation.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Neonatal withdrawal symptoms have been reported. Not recommended during breastfeeding due to excretion into breast milk and potential adverse effects on the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months
Availability
Pharmacies, hospitals
Approval Status
FDA Approved
Patent Status
Generic available
Clinical Trials
Extensive clinical trials support efficacy in Major Depressive Disorder, Generalized Anxiety Disorder, Panic Disorder, and Social Anxiety Disorder.
Lab Monitoring
- Blood pressure monitoring (especially at initiation and dose escalation).
- Serum sodium levels (if hyponatremia is suspected).
- Liver function tests (periodically).
Doctor Notes
- Gradual titration is essential for both initiation and discontinuation to minimize adverse effects.
- Monitor blood pressure regularly, especially at higher doses, due to potential for dose-related increases.
- Counsel patients on potential sexual side effects and symptoms of serotonin syndrome.
Patient Guidelines
- Do not stop taking abruptly; consult doctor for tapering.
- Report any unusual changes in mood or behavior immediately.
- Avoid alcohol while on this medication.
- Take with food to minimize gastrointestinal upset.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness, drowsiness, or visual disturbances. Advise caution when driving or operating machinery until effects are known.
Lifestyle Advice
- Regular exercise
- Balanced diet
- Adequate sleep
- Stress management techniques
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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