Ventilast
Generic Name
Montelukast 10 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ventilast 10 mg tablet | ৳ 14.50 | ৳ 145.00 |
Description
Overview of the medicine
Montelukast is a leukotriene receptor antagonist used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.
Uses & Indications
Dosage
Adults
10 mg once daily, in the evening for asthma or as needed for allergic rhinitis.
Elderly
No dosage adjustment generally needed.
Renal_impairment
No dosage adjustment needed.
How to Take
Oral. Take once daily in the evening for asthma. For allergic rhinitis, take once daily, timing depends on patient needs. Can be taken with or without food.
Mechanism of Action
Montelukast selectively antagonizes the CysLT1 receptor, thereby inhibiting the actions of cysteinyl leukotrienes (LTC4, LTD4, LTE4). These leukotrienes are potent inflammatory mediators released from various cells, including mast cells and eosinophils, and are implicated in asthma and allergic rhinitis.
Pharmacokinetics
Onset
Clinical improvement usually within 1 day for asthma; within 1 day for allergic rhinitis.
Excretion
Primarily excreted in feces via bile (approximately 86%), with minimal renal excretion (less than 0.2%).
Half life
Approximately 2.7 to 5.5 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are achieved in approximately 2-4 hours.
Metabolism
Extensively metabolized in the liver by CYP2C8, CYP3A4, and CYP2C9.
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any component of the tablet
Drug Interactions
Rifampin
May decrease montelukast plasma levels.
Phenobarbital
May decrease montelukast plasma levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed during pregnancy. Excreted in breast milk, caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any component of the tablet
Drug Interactions
Rifampin
May decrease montelukast plasma levels.
Phenobarbital
May decrease montelukast plasma levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed during pregnancy. Excreted in breast milk, caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated efficacy and safety for asthma and allergic rhinitis in adults and pediatric patients. Ongoing post-marketing surveillance continues to monitor safety profiles.
Lab Monitoring
- Routine lab monitoring is generally not required unless clinically indicated for specific patient conditions.
Doctor Notes
- Educate patients on the difference between daily maintenance therapy and rescue medication.
- Counsel patients on potential neuropsychiatric symptoms and to report any changes immediately.
- Consider alternative treatments if neuropsychiatric symptoms develop or worsen.
Patient Guidelines
- Take as directed by your doctor, usually once daily in the evening.
- Do not stop taking this medication without consulting your doctor, even if you feel better.
- This medicine is not for sudden asthma attacks; use a fast-acting inhaler for acute attacks.
Missed Dose Advice
If a dose is missed, take the next dose at the regular time. Do not take a double dose to make up for a missed dose.
Driving Precautions
May cause dizziness or drowsiness in some individuals. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid known asthma triggers.
- Maintain a healthy lifestyle with regular exercise (if appropriate) and a balanced diet.
- Follow up regularly with your healthcare provider.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.