Vercef
Generic Name
Cefixime Pediatric Drop
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vercef 20 mg pediatric drop | ৳ 60.00 | N/A |
Description
Overview of the medicine
Vercef 20 mg Pediatric Drop is a broad-spectrum antibiotic used to treat various bacterial infections in children.
Uses & Indications
Dosage
Adults
Not indicated for adults; this is a pediatric formulation.
Elderly
Not indicated for elderly; this is a pediatric formulation.
Pediatric
General pediatric dose: 8 mg/kg/day, given as a single daily dose or in two divided doses every 12 hours. For infants less than 6 months, consult a physician.
Renal_impairment
Dosage adjustment is necessary for children with severe renal impairment. Consult a physician for specific dosage based on creatinine clearance.
How to Take
Administer orally. Shake the bottle well before each use. Can be given with or without food. Use the provided dropper/measuring spoon for accurate dosing.
Mechanism of Action
Cefixime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Clinical effects typically observed within 2-6 hours after administration.
Excretion
Primarily excreted unchanged in the urine (about 50-60%) and also via biliary route.
Half life
Plasma elimination half-life is typically 3-4 hours.
Absorption
Approximately 40-50% orally absorbed. Food can slightly delay absorption but does not significantly affect the extent.
Metabolism
Limited hepatic metabolism. Most of the drug is excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics
- History of serious hypersensitivity reactions to penicillin antibiotics
Drug Interactions
Warfarin
May increase prothrombin time (INR) with concurrent use. Monitor coagulation parameters.
Nifedipine
May increase cefixime peak plasma concentrations and AUC.
Probenecid
May increase cefixime plasma concentrations by inhibiting renal excretion.
Carbamazepine
Elevated carbamazepine levels have been reported with concurrent cefixime use.
Storage
Store dry powder below 30°C, protected from light and moisture. After reconstitution, store in a refrigerator (2-8°C) and discard any unused portion after the specified period.
Overdose
In case of overdose, symptoms may include nausea, vomiting, abdominal pain, and diarrhea. Management includes gastric lavage and general supportive measures. Hemodialysis or peritoneal dialysis is not effective in removing cefixime.
Pregnancy & Lactation
Pregnancy Category B. Cefixime should be used during pregnancy only if clearly needed. Caution should be exercised when administered to a nursing mother. Consult a physician.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics
- History of serious hypersensitivity reactions to penicillin antibiotics
Drug Interactions
Warfarin
May increase prothrombin time (INR) with concurrent use. Monitor coagulation parameters.
Nifedipine
May increase cefixime peak plasma concentrations and AUC.
Probenecid
May increase cefixime plasma concentrations by inhibiting renal excretion.
Carbamazepine
Elevated carbamazepine levels have been reported with concurrent cefixime use.
Storage
Store dry powder below 30°C, protected from light and moisture. After reconstitution, store in a refrigerator (2-8°C) and discard any unused portion after the specified period.
Overdose
In case of overdose, symptoms may include nausea, vomiting, abdominal pain, and diarrhea. Management includes gastric lavage and general supportive measures. Hemodialysis or peritoneal dialysis is not effective in removing cefixime.
Pregnancy & Lactation
Pregnancy Category B. Cefixime should be used during pregnancy only if clearly needed. Caution should be exercised when administered to a nursing mother. Consult a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Dry powder: 2-3 years. Reconstituted suspension: 7-14 days when stored in a refrigerator (2-8°C).
Availability
Available in pharmacies and hospitals
Approval Status
Approved by health authorities like DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Cefixime in treating various bacterial infections in pediatric patients.
Lab Monitoring
- Renal function tests (for prolonged therapy or in patients with renal impairment)
- Complete blood count (CBC) for prolonged treatment
- Liver function tests (rarely needed, but possible if concerns arise)
Doctor Notes
- Emphasize the importance of completing the full course of therapy to prevent resistance.
- Advise parents to monitor for signs of allergic reactions or severe diarrhea.
- Adjust dose in renal impairment. For pediatric use only.
Patient Guidelines
- Complete the full course of treatment, even if symptoms improve.
- Do not share this medicine with others.
- Shake the bottle well before each use.
- Store as directed by the pharmacist.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Cefixime is generally not expected to impair the ability to drive or operate machinery. However, if side effects like dizziness occur, avoid such activities.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Ensure adequate fluid intake to stay hydrated.
- Avoid self-medication with antibiotics.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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