Veri-kit
Generic Name
Mifepristone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| veri kit 200 mg tablet | ৳ 300.00 | N/A |
Description
Overview of the medicine
Mifepristone 200 mg is an anti-progesterone medication used for medical termination of early pregnancy (up to 63 days of gestation) in combination with misoprostol. It blocks the effects of progesterone, which is necessary for maintaining pregnancy.
Uses & Indications
Dosage
Adults
200 mg orally as a single dose, followed by Misoprostol 800 mcg orally or vaginally 24-48 hours later.
Elderly
No specific dosage adjustment required, but caution is advised due to potential comorbidities.
Renal_impairment
No specific guidelines; caution and monitoring are recommended.
How to Take
Oral administration with water. It should be taken under medical supervision.
Mechanism of Action
It is a synthetic steroid that competitively binds to progesterone receptors, leading to the detachment of the conceptus from the uterine wall and softening of the cervix. It also sensitizes the myometrium to prostaglandin-induced contractions.
Pharmacokinetics
Onset
Uterine contractions and cervical changes typically begin within 24-48 hours after administration.
Excretion
Primarily through feces (83%), with a smaller portion excreted in urine (9%).
Half life
Approximately 18-36 hours for the parent compound, with active metabolites having a longer half-life.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached within 1.5 hours. Bioavailability is about 69%.
Metabolism
Primarily hepatic (liver) metabolism via CYP3A4, with extensive first-pass effect.
Side Effects
Contraindications
- Confirmed or suspected ectopic pregnancy
- Chronic adrenal failure
- Hemorrhagic disorders or concurrent anticoagulant therapy
- Inherited porphyria
- Hypersensitivity to mifepristone or any component
Drug Interactions
NSAIDs
Potential interaction with misoprostol (often used with mifepristone).
CYP3A4 Inducers
May decrease mifepristone levels (e.g., Rifampicin, Phenytoin).
Corticosteroids
Mifepristone can counteract the effects of corticosteroids.
CYP3A4 Inhibitors
May increase mifepristone levels (e.g., Ketoconazole, Grapefruit juice).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Symptomatic treatment and supportive care should be provided.
Pregnancy & Lactation
Used to terminate pregnancy. Not recommended during breastfeeding as mifepristone and its metabolites may pass into breast milk.
Side Effects
Contraindications
- Confirmed or suspected ectopic pregnancy
- Chronic adrenal failure
- Hemorrhagic disorders or concurrent anticoagulant therapy
- Inherited porphyria
- Hypersensitivity to mifepristone or any component
Drug Interactions
NSAIDs
Potential interaction with misoprostol (often used with mifepristone).
CYP3A4 Inducers
May decrease mifepristone levels (e.g., Rifampicin, Phenytoin).
Corticosteroids
Mifepristone can counteract the effects of corticosteroids.
CYP3A4 Inhibitors
May increase mifepristone levels (e.g., Ketoconazole, Grapefruit juice).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Symptomatic treatment and supportive care should be provided.
Pregnancy & Lactation
Used to terminate pregnancy. Not recommended during breastfeeding as mifepristone and its metabolites may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months.
Availability
Pharmacies, Hospitals, Clinics
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established its efficacy and safety for medical termination of pregnancy since the 1980s. Ongoing research for other indications.
Lab Monitoring
- Confirmation of pregnancy location and gestational age (ultrasound)
- Hemoglobin levels (if significant bleeding occurs)
Doctor Notes
- Ensure proper patient counseling regarding the procedure, expected outcomes, and potential risks.
- Confirm gestational age and rule out ectopic pregnancy before administration.
- Provide clear instructions for misoprostol administration and follow-up.
Patient Guidelines
- Read the patient information leaflet carefully.
- Attend all follow-up appointments.
- Be aware of potential heavy bleeding and cramping.
- Contact a doctor immediately if you experience fever, severe pain, or prolonged heavy bleeding.
Missed Dose Advice
Not applicable for a single-dose regimen. If part of a multi-drug regimen, consult physician.
Driving Precautions
May cause dizziness or fatigue. Avoid driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Avoid strenuous activities immediately after the procedure.
- Maintain good hygiene.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.