Verifen-SR
Generic Name
Diclofenac Sodium 100 mg Sustained Release Capsule
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| verifen sr 100 mg capsule | ৳ 3.01 | ৳ 30.10 |
Description
Overview of the medicine
Verifen-SR 100 mg Capsule contains Diclofenac Sodium, a non-steroidal anti-inflammatory drug (NSAID) used for the relief of pain, inflammation, and fever. The sustained-release formulation provides prolonged therapeutic effects.
Uses & Indications
Dosage
Adults
Usually 100 mg once daily. Max 100 mg/day for sustained release formulation.
Elderly
Lower doses may be required, close monitoring for adverse effects is recommended.
Renal_impairment
Use with caution; dose adjustment may be necessary in severe impairment. Not recommended for severe renal failure.
How to Take
Take the capsule whole with a glass of water, preferably after a meal to reduce gastrointestinal upset. Do not chew or crush.
Mechanism of Action
Diclofenac inhibits cyclooxygenase (COX-1 and COX-2) enzymes, leading to a reduction in the synthesis of prostaglandins. Prostaglandins are mediators of pain, inflammation, and fever, so their reduction results in analgesic, anti-inflammatory, and antipyretic effects.
Pharmacokinetics
Onset
Pain relief typically begins within 1 hour; full anti-inflammatory effect may take several days.
Excretion
Excreted mainly through urine (approx. 60%) as metabolites and bile (approx. 35%).
Half life
Approximately 1-2 hours for immediate release; sustained release prolongs effective plasma levels for up to 24 hours.
Absorption
Well absorbed from the GI tract after oral administration. Sustained-release formulation ensures prolonged absorption.
Metabolism
Extensively metabolized in the liver, primarily by hydroxylation and methoxylation, followed by glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to diclofenac or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after aspirin or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery (peri-operative pain)
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Corticosteroids
Increased risk of gastrointestinal ulceration and bleeding.
Lithium, Digoxin, Methotrexate
Increased plasma levels of these drugs.
Warfarin, other anticoagulants
Increased risk of bleeding.
Diuretics, ACE inhibitors, Angiotensin II Receptor Blockers (ARBs)
Reduced antihypertensive effect; increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include lethargy, drowsiness, nausea, vomiting, epigastric pain, GI bleeding, hypotension, respiratory depression, and coma. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Category C in early pregnancy; contraindicated in the third trimester due to risk of premature closure of the fetal ductus arteriosus. Not recommended during breastfeeding as it is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to diclofenac or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after aspirin or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery (peri-operative pain)
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Corticosteroids
Increased risk of gastrointestinal ulceration and bleeding.
Lithium, Digoxin, Methotrexate
Increased plasma levels of these drugs.
Warfarin, other anticoagulants
Increased risk of bleeding.
Diuretics, ACE inhibitors, Angiotensin II Receptor Blockers (ARBs)
Reduced antihypertensive effect; increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include lethargy, drowsiness, nausea, vomiting, epigastric pain, GI bleeding, hypotension, respiratory depression, and coma. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Category C in early pregnancy; contraindicated in the third trimester due to risk of premature closure of the fetal ductus arteriosus. Not recommended during breastfeeding as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved by drug regulatory authorities worldwide
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of diclofenac in various inflammatory and painful conditions. Sustained-release formulations are designed to improve patient compliance and reduce dosing frequency.
Lab Monitoring
- Complete blood count (CBC) for prolonged therapy
- Liver function tests (LFTs) periodically
- Renal function tests (e.g., serum creatinine, BUN) periodically
- Blood pressure monitoring
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Monitor for cardiovascular and gastrointestinal adverse events, especially in high-risk patients.
- Assess renal and hepatic function periodically during long-term therapy.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Swallow the capsule whole; do not chew, crush, or break it.
- Take with food or milk to minimize stomach upset.
- Inform your doctor about all other medications you are taking.
- Report any unusual bleeding, persistent stomach pain, or dark stools immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness or drowsiness in some individuals. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid alcohol consumption, as it may increase the risk of stomach irritation and bleeding.
- Avoid smoking, as it may worsen GI side effects.
- Maintain a healthy diet and stay hydrated.
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