Verigold
Generic Name
Betahistine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| verigold tablet | ৳ 8.00 | ৳ 240.00 |
Description
Overview of the medicine
Betahistine is used to treat symptoms of Meniere's disease, such as vertigo (dizziness), tinnitus (ringing in the ears), and hearing loss.
Uses & Indications
Dosage
Adults
Initial dose 8-16 mg three times daily, or 24 mg twice daily, adjusted based on response. Maintenance dose usually 24-48 mg daily.
Elderly
No specific dose adjustments are required, but caution is advised in elderly patients.
Renal_impairment
Use with caution. Dosage adjustments may be considered based on clinical judgment.
How to Take
Tablets should be taken orally, preferably with or after meals to avoid gastrointestinal upset.
Mechanism of Action
It acts as a weak H1 receptor agonist and a potent H3 receptor antagonist in the inner ear. It increases blood flow to the inner ear, helping to reduce endolymphatic pressure.
Pharmacokinetics
Onset
Clinical improvement typically seen within a few weeks of treatment; full effect may take longer.
Excretion
Primarily via urine as its major metabolite, 2-PAA.
Half life
Approximately 3-4 hours for its active metabolite, 2-pyridylacetic acid.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract.
Metabolism
Extensively metabolized to 2-pyridylacetic acid (2-PAA) through oxidative deamination.
Side Effects
Contraindications
- Hypersensitivity to betahistine or any component of the formulation
- Pheochromocytoma (a rare tumor of the adrenal gland)
Drug Interactions
Antihistamines
May reduce the efficacy of betahistine. Concurrent use is generally not recommended.
Monoamine Oxidase (MAO) inhibitors
May increase exposure to betahistine, requiring caution.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, drowsiness, and convulsions at very high doses. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed and the potential benefit outweighs the potential risk. Not recommended during breastfeeding due to lack of data.
Side Effects
Contraindications
- Hypersensitivity to betahistine or any component of the formulation
- Pheochromocytoma (a rare tumor of the adrenal gland)
Drug Interactions
Antihistamines
May reduce the efficacy of betahistine. Concurrent use is generally not recommended.
Monoamine Oxidase (MAO) inhibitors
May increase exposure to betahistine, requiring caution.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, drowsiness, and convulsions at very high doses. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed and the potential benefit outweighs the potential risk. Not recommended during breastfeeding due to lack of data.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Numerous clinical trials have supported the efficacy of betahistine in reducing the frequency and severity of vertigo attacks associated with Meniere's disease.
Lab Monitoring
- Routine lab monitoring is generally not required for betahistine.
Doctor Notes
- Educate patients on the chronic nature of Meniere's disease and the expected timeline for symptom improvement with betahistine.
- Advise patients about potential side effects and when to seek medical attention.
- Remind patients to avoid sudden head movements and follow dietary recommendations if applicable.
Patient Guidelines
- Do not stop taking the medicine abruptly; complete the full course as prescribed.
- Inform your doctor if your symptoms worsen or if you experience any unusual side effects.
- Take with food if you experience stomach upset.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
Betahistine may cause drowsiness or dizziness in some individuals. Caution should be exercised when driving or operating machinery.
Lifestyle Advice
- Avoid sudden head movements which can trigger vertigo.
- Manage stress as it can exacerbate Meniere's symptoms.
- Limit intake of salt, caffeine, and alcohol as they can worsen Meniere's disease.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.