Verivas
Generic Name
Solifenacin Succinate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| verivas 5 mg tablet | ৳ 50.00 | ৳ 500.00 |
Description
Overview of the medicine
Verivas 5 mg Tablet contains Solifenacin Succinate, which is used to treat symptoms of overactive bladder, such as urinary urgency, frequency, and urge incontinence. It works by relaxing the bladder muscles, helping to control urination.
Uses & Indications
Dosage
Adults
The recommended starting dose is 5 mg once daily. If needed, the dose may be increased to 10 mg once daily.
Elderly
No dosage adjustment is required in elderly patients.
Renal_impairment
For patients with severe renal impairment (creatinine clearance < 30 mL/min), a dose greater than 5 mg is not recommended.
How to Take
Take the tablet orally once daily with water, with or without food. Swallow the tablet whole; do not crush, chew, or divide it.
Mechanism of Action
Solifenacin is a competitive muscarinic receptor antagonist. It inhibits muscarinic M3 receptors in the bladder, which are primarily responsible for bladder smooth muscle contraction. By blocking these receptors, it reduces bladder muscle activity, thereby increasing bladder capacity and decreasing the frequency of urination, urgency, and incontinence episodes.
Pharmacokinetics
Onset
Clinical effects usually observed within 1 week, with full effect within 4 weeks.
Excretion
Eliminated mainly in the urine (about 70%) and feces (about 15-20%).
Half life
Approximately 45-68 hours.
Absorption
Well absorbed from the gastrointestinal tract, reaching peak plasma concentrations in 3-8 hours. Bioavailability is about 90%.
Metabolism
Extensively metabolized in the liver, primarily by cytochrome P450 3A4 (CYP3A4) enzyme. Active metabolites exist but contribute minimally to clinical effect.
Side Effects
Contraindications
- Urinary retention
- Gastric retention
- Uncontrolled narrow-angle glaucoma
- Severe hepatic impairment
- Known hypersensitivity to solifenacin succinate or any component of the product.
Drug Interactions
Anticholinergic agents
Concomitant use with other anticholinergic agents may lead to more pronounced anticholinergic adverse effects.
Cholinergic receptor agonists
May reduce the effect of cholinergic receptor agonists.
CYP3A4 Inhibitors (e.g., Ketoconazole)
Co-administration with strong CYP3A4 inhibitors like ketoconazole may increase solifenacin exposure, requiring a dose reduction of solifenacin to 5 mg.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe anticholinergic effects such as dry mouth, blurred vision, constipation, urinary retention, and tachycardia. Treatment should be symptomatic and supportive. Gastric lavage and activated charcoal may be considered. Physostigmine can be used for severe anticholinergic symptoms.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. It is not known if solifenacin is excreted in human milk; therefore, caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Urinary retention
- Gastric retention
- Uncontrolled narrow-angle glaucoma
- Severe hepatic impairment
- Known hypersensitivity to solifenacin succinate or any component of the product.
Drug Interactions
Anticholinergic agents
Concomitant use with other anticholinergic agents may lead to more pronounced anticholinergic adverse effects.
Cholinergic receptor agonists
May reduce the effect of cholinergic receptor agonists.
CYP3A4 Inhibitors (e.g., Ketoconazole)
Co-administration with strong CYP3A4 inhibitors like ketoconazole may increase solifenacin exposure, requiring a dose reduction of solifenacin to 5 mg.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe anticholinergic effects such as dry mouth, blurred vision, constipation, urinary retention, and tachycardia. Treatment should be symptomatic and supportive. Gastric lavage and activated charcoal may be considered. Physostigmine can be used for severe anticholinergic symptoms.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. It is not known if solifenacin is excreted in human milk; therefore, caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies nationwide in Bangladesh
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of solifenacin in treating overactive bladder symptoms.
Lab Monitoring
- No specific routine lab monitoring is required.
- Monitor renal and hepatic function in patients with pre-existing impairment.
Doctor Notes
- Advise patients about potential anticholinergic side effects, particularly dry mouth and constipation, and strategies to manage them.
- Caution in patients with pre-existing cardiovascular disease due to potential for QT prolongation (rare).
Patient Guidelines
- Take the medicine as directed by your doctor, preferably at the same time each day.
- Do not stop taking the medicine abruptly without consulting your doctor.
- Report any severe side effects such as difficulty urinating, eye pain, or allergic reactions to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause blurred vision, dizziness, or somnolence. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain adequate hydration, but avoid excessive fluid intake, especially before bedtime.
- Avoid caffeine and alcohol, as they can irritate the bladder.
- Do pelvic floor exercises (Kegel exercises) as recommended by your doctor to strengthen bladder control.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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