Vermizol
Generic Name
Albendazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vermizol 100 mg chewable tablet | ৳ 0.74 | ৳ 4.44 |
Description
Overview of the medicine
Vermizol 100 mg Chewable Tablet is an anti-parasitic medication containing Albendazole, used to treat various worm infections such as roundworms, tapeworms, and other parasitic infestations.
Uses & Indications
Dosage
Adults
For common intestinal worms (e.g., Ascaris, hookworm, pinworm, whipworm): 400 mg (four 100 mg tablets) as a single dose. For Strongyloidiasis or Taeniasis: 400 mg (four 100 mg tablets) once daily for 3 days. For Hydatid disease or Neurocysticercosis: Dosage and duration vary, consult physician.
Elderly
Generally same as adults, but caution should be exercised in elderly patients with hepatic or renal impairment.
Renal_impairment
No specific dose adjustment is required for mild to moderate renal impairment. Use with caution in severe impairment.
How to Take
The chewable tablet can be chewed, crushed, or mixed with a small amount of water and swallowed. It should be taken with food, preferably a fatty meal, to enhance absorption.
Mechanism of Action
It binds to beta-tubulin, inhibiting microtubule polymerization in parasitic worms, thereby impairing glucose uptake and depleting energy stores, leading to immobilization and death of the worm.
Pharmacokinetics
Onset
Active metabolite appears in plasma within 2-5 hours. Onset of therapeutic effect varies depending on the parasite type and location.
Excretion
Albendazole sulfoxide and other metabolites are primarily excreted in the urine, with a small amount in bile.
Half life
The plasma half-life of its active metabolite, albendazole sulfoxide, is typically 8-12 hours.
Absorption
Poorly absorbed orally, but absorption is significantly increased when taken with a fatty meal.
Metabolism
Undergoes extensive first-pass metabolism in the liver to its primary active metabolite, albendazole sulfoxide.
Side Effects
Contraindications
- Hypersensitivity to Albendazole or any component of the formulation.
- First trimester of pregnancy (due to potential teratogenicity).
Drug Interactions
Cimetidine
May increase plasma levels of albendazole sulfoxide.
Praziquantel
May increase plasma levels of albendazole sulfoxide.
Theophylline
Albendazole may decrease plasma levels of theophylline; monitor theophylline levels.
Dexamethasone
May increase plasma levels of albendazole sulfoxide.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of an overdose, symptomatic and supportive treatment should be initiated. Gastric lavage and appropriate medical monitoring may be necessary.
Pregnancy & Lactation
Pregnancy Category C. Should be avoided during the first trimester of pregnancy due to potential teratogenic effects. Use with caution during lactation; consult a healthcare professional.
Side Effects
Contraindications
- Hypersensitivity to Albendazole or any component of the formulation.
- First trimester of pregnancy (due to potential teratogenicity).
Drug Interactions
Cimetidine
May increase plasma levels of albendazole sulfoxide.
Praziquantel
May increase plasma levels of albendazole sulfoxide.
Theophylline
Albendazole may decrease plasma levels of theophylline; monitor theophylline levels.
Dexamethasone
May increase plasma levels of albendazole sulfoxide.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of an overdose, symptomatic and supportive treatment should be initiated. Gastric lavage and appropriate medical monitoring may be necessary.
Pregnancy & Lactation
Pregnancy Category C. Should be avoided during the first trimester of pregnancy due to potential teratogenic effects. Use with caution during lactation; consult a healthcare professional.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Generally 2 to 3 years from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Patent expired, generic versions available
WHO Essential Medicine
YesClinical Trials
Albendazole has been extensively studied in numerous clinical trials demonstrating its efficacy and safety across various parasitic infections globally.
Lab Monitoring
- Liver function tests (LFTs) should be performed before and periodically during prolonged therapy or high doses.
- Complete blood counts (CBC) should be monitored, especially in patients receiving high doses or prolonged treatment.
Doctor Notes
- Emphasize the importance of completing the full course of treatment to prevent recurrence.
- Monitor liver function tests and blood counts for patients on prolonged or high-dose therapy.
Patient Guidelines
- Complete the full course of treatment as prescribed by your doctor, even if you feel better.
- Take the medicine with food, preferably a fatty meal, to improve absorption.
- Inform your doctor about any unusual or severe side effects immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness in some individuals. If you experience dizziness, avoid driving or operating heavy machinery.
Lifestyle Advice
- Practice good hygiene, such as frequent handwashing, to prevent re-infection.
- Ensure proper sanitation and avoid consuming contaminated food or water.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.