Vesinac
Generic Name
Solifenacin Succinate
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vesinac 5 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Solifenacin is used to treat symptoms of overactive bladder (OAB), such as urinary urgency, frequency, and incontinence.
Uses & Indications
Dosage
Adults
Initially 5 mg once daily; may be increased to 10 mg once daily based on response and tolerability.
Elderly
No dose adjustment generally needed, but use with caution.
Renal_impairment
Mild to moderate: No adjustment. Severe (CrCl < 30 mL/min): Max 5 mg daily.
How to Take
Orally, with water, with or without food.
Mechanism of Action
Solifenacin is a competitive muscarinic receptor antagonist. It specifically binds to M3 muscarinic receptors in the bladder, inhibiting bladder contraction and thus reducing urgency, frequency, and incontinence associated with OAB.
Pharmacokinetics
Onset
1-2 hours, full effect within 1 week.
Excretion
Primarily in urine (approx 70%) and feces (approx 23%).
Half life
Approximately 45-68 hours.
Absorption
Well absorbed, peak plasma concentration reached in 3-8 hours. Bioavailability approx 90%.
Metabolism
Primarily in the liver by CYP3A4.
Side Effects
Contraindications
- Urinary retention, gastric retention, uncontrolled narrow-angle glaucoma.
- Severe hepatic impairment.
- Hypersensitivity to the active substance or any excipients.
Drug Interactions
Other anticholinergics
Potentiate effects and side effects.
CYP3A4 inducers (e.g., rifampicin)
Decrease solifenacin levels.
CYP3A4 inhibitors (e.g., ketoconazole)
Increase solifenacin levels.
Storage
Store below 30°C in a dry place, away from light.
Overdose
Symptoms include severe anticholinergic effects. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Not recommended during breastfeeding.
Side Effects
Contraindications
- Urinary retention, gastric retention, uncontrolled narrow-angle glaucoma.
- Severe hepatic impairment.
- Hypersensitivity to the active substance or any excipients.
Drug Interactions
Other anticholinergics
Potentiate effects and side effects.
CYP3A4 inducers (e.g., rifampicin)
Decrease solifenacin levels.
CYP3A4 inhibitors (e.g., ketoconazole)
Increase solifenacin levels.
Storage
Store below 30°C in a dry place, away from light.
Overdose
Symptoms include severe anticholinergic effects. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Not recommended during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Extensive trials have shown efficacy and safety in OAB patients.
Lab Monitoring
- Renal function (CrCl) in severe renal impairment.
- Liver function in severe hepatic impairment.
Doctor Notes
- Assess for other causes of urinary frequency before initiating treatment.
- Monitor for signs of urinary retention, especially in patients with bladder outflow obstruction.
Patient Guidelines
- Take as prescribed, do not crush or chew the tablet.
- Report any severe side effects like urinary retention immediately.
- Avoid alcohol, as it may worsen drowsiness.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not double dose.
Driving Precautions
May cause blurred vision, dizziness, or drowsiness. Avoid driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Maintain adequate fluid intake.
- Manage constipation with diet and fiber if needed.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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