For external use only. Apply a thin layer to the affected area and gently rub it in. Wash hands before and after application. Avoid contact with eyes, mouth, and other mucous membranes. Do not use on the face, groin, or axillae unless directed by a physician. Do not use with occlusive dressings unless specifically instructed.

Clobetasol Propionate exerts anti-inflammatory, antipruritic, and vasoconstrictive effects by inducing phospholipase A2 inhibitory proteins, lipocortins. These proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Neomycin Sulfate is an aminoglycoside antibiotic that inhibits bacterial protein synthesis by irreversibly binding to the 30S ribosomal subunit, leading to bacterial cell death.

• •Hypersensitivity to Clobetasol Propionate, Neomycin Sulfate, or any other components of the cream.
• •Rosacea, acne vulgaris, perioral dermatitis.
• •Untreated fungal, viral, or primary bacterial skin infections.
• •Pruritus without inflammation.
• •Perianal and genital pruritus.

Store below 30°C. Do not freeze. Keep out of reach of children.

Topical overdose is unlikely to cause acute problems. However, chronic overdose or misuse can lead to systemic effects of hypercorticism (e.g., Cushing's syndrome) and, with neomycin, potential ototoxicity or nephrotoxicity with significant absorption. Treatment is symptomatic and supportive. Gradual withdrawal of the steroid may be necessary.

Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Avoid prolonged use or large quantities during pregnancy. It is unknown whether topically administered corticosteroids are excreted in human milk. Use with caution during lactation. Neomycin is poorly absorbed topically, but caution is advised.