Vesotan
Generic Name
Betahistine
Manufacturer
General Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vesotan 16 mg tablet | ৳ 11.03 | ৳ 110.30 |
Description
Overview of the medicine
Vesotan 16 mg Tablet contains Betahistine, which is used to treat symptoms of Meniere's disease, such as dizziness (vertigo), ringing in the ears (tinnitus), and hearing loss.
Uses & Indications
Dosage
Adults
Typically 8-16 mg three times daily, preferably with meals. The dose may be adjusted based on clinical response.
Elderly
No specific dosage adjustment is required, but caution is advised in elderly patients with co-morbidities.
Renal_impairment
No specific dosage adjustment required, but caution is advised in patients with severe renal impairment.
How to Take
Take the tablet orally with water, preferably with meals to reduce gastrointestinal upset. Do not crush or chew the tablet.
Mechanism of Action
Betahistine acts as a weak Histamine H1-receptor agonist and a potent Histamine H3-receptor antagonist. It is thought to increase histamine turnover in the central nervous system and improve microcirculation in the inner ear, thereby reducing symptoms of Meniere's disease.
Pharmacokinetics
Onset
Symptomatic improvement may take several weeks or months of continuous treatment.
Excretion
Excreted almost entirely in the urine as 2-PAA within 24 hours.
Half life
Approximately 3-4 hours.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 1 hour.
Metabolism
Rapidly and extensively metabolized primarily to 2-pyridylacetic acid (2-PAA), an inactive metabolite.
Side Effects
Contraindications
- Hypersensitivity to betahistine or any component of the tablet
- Pheochromocytoma (a rare tumor of the adrenal gland)
Drug Interactions
Antihistamines
May reduce the effect of betahistine. Concomitant use should be avoided.
Monoamine Oxidase Inhibitors (MAOIs)
May increase the exposure to betahistine. Caution is advised.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, abdominal pain, drowsiness, and convulsions (especially at very high doses). Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during lactation as it is unknown if betahistine is excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to betahistine or any component of the tablet
- Pheochromocytoma (a rare tumor of the adrenal gland)
Drug Interactions
Antihistamines
May reduce the effect of betahistine. Concomitant use should be avoided.
Monoamine Oxidase Inhibitors (MAOIs)
May increase the exposure to betahistine. Caution is advised.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, abdominal pain, drowsiness, and convulsions (especially at very high doses). Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during lactation as it is unknown if betahistine is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved in many countries for Meniere's disease
Patent Status
Off-patent (Generic available)
Clinical Trials
Numerous clinical trials have investigated the efficacy and safety of betahistine in Meniere's disease and vertigo.
Lab Monitoring
- Routine lab monitoring is generally not required for betahistine therapy.
Doctor Notes
- Prescribe with caution in patients with bronchial asthma or a history of peptic ulcer due to its histamine analogue properties.
- Advise patients that full therapeutic effects may take time.
Patient Guidelines
- Take the medicine regularly as prescribed by your doctor.
- It may take several weeks or months to see the full benefits of the treatment.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
Betahistine is not expected to affect the ability to drive or operate machinery, but patients experiencing dizziness or other side effects should exercise caution.
Lifestyle Advice
- Avoid excessive caffeine and alcohol as they can sometimes aggravate vertigo.
- Maintain a low-salt diet if advised by your doctor for Meniere's disease.
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International brand names for this medicine. Click a brand to search for detailed information.
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