Vestar-MR
Generic Name
Trimetazidine Dihydrochloride 35 mg Modified-Release Tablet
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vestar mr 35 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Trimetazidine is a metabolic agent used to prevent angina attacks and treat other conditions like vertigo and tinnitus. The modified-release formulation allows for once or twice daily dosing.
Uses & Indications
Dosage
Adults
1 tablet (35 mg) twice daily, morning and evening, during meals.
Elderly
Dosage adjustment may not be required. However, caution is advised in patients with moderate renal impairment.
Renal_impairment
For patients with moderate renal impairment (creatinine clearance 30-60 mL/min), the recommended dose is 1 tablet (35 mg) once daily, in the morning, during breakfast.
How to Take
To be taken orally, with meals. Swallow the tablet whole with a glass of water, do not chew or crush.
Mechanism of Action
Trimetazidine preserves myocardial energy metabolism during ischemia. It does this by shifting the myocardial glucose oxidation from fatty acid oxidation, thereby enhancing glucose utilization and improving ATP production.
Pharmacokinetics
Onset
Clinical effects typically observed within 2 weeks of regular use.
Excretion
Primarily eliminated unchanged in the urine.
Half life
Approximately 4-6 hours for the standard release, but prolonged for modified-release formulations (around 7 hours for 35mg MR).
Absorption
Rapidly and almost completely absorbed after oral administration. Peak plasma concentration reached within 2-3 hours.
Metabolism
Minimal hepatic metabolism.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients
- Parkinson's disease, Parkinsonian symptoms, tremors, restless leg syndrome and other related movement disorders
- Severe renal impairment (creatinine clearance < 30 mL/min)
Drug Interactions
No significant interactions
No significant drug interactions have been reported with Trimetazidine.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited data available. In case of overdose, symptomatic treatment should be initiated. Contact your doctor or nearest hospital immediately.
Pregnancy & Lactation
Not recommended during pregnancy and lactation due to lack of sufficient data. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients
- Parkinson's disease, Parkinsonian symptoms, tremors, restless leg syndrome and other related movement disorders
- Severe renal impairment (creatinine clearance < 30 mL/min)
Drug Interactions
No significant interactions
No significant drug interactions have been reported with Trimetazidine.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited data available. In case of overdose, symptomatic treatment should be initiated. Contact your doctor or nearest hospital immediately.
Pregnancy & Lactation
Not recommended during pregnancy and lactation due to lack of sufficient data. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Numerous clinical trials have demonstrated the efficacy and safety of Trimetazidine in patients with angina pectoris and other ischemic conditions.
Lab Monitoring
- No specific routine lab monitoring is required for Trimetazidine.
Doctor Notes
- Advise patients about potential for Parkinsonian symptoms and to report any new movement disorders.
- Careful assessment of renal function before prescribing, especially for elderly patients.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
Trimetazidine may cause dizziness and drowsiness, which could affect the ability to drive or operate machinery. Patients should be cautious.
Lifestyle Advice
- Maintain a healthy diet and regular exercise to support heart health.
- Avoid smoking and limit alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.