Vidox
Generic Name
Doxycycline
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vidox 100 mg capsule | ৳ 2.00 | ৳ 20.00 |
Description
Overview of the medicine
Vidox 100 mg Capsule contains Doxycycline, a broad-spectrum tetracycline antibiotic used to treat a wide range of bacterial infections including respiratory, urinary tract, skin, and sexually transmitted infections. It is also effective against certain parasitic infections like malaria and in the treatment of acne.
Uses & Indications
Dosage
Adults
Typical dose is 100 mg orally every 12-24 hours depending on the infection. For severe infections, 200 mg on the first day (100 mg every 12 hours) followed by 100 mg daily or 50 mg every 12 hours. For acne, 50 mg once daily for 6-12 weeks. For malaria prophylaxis, 100 mg once daily starting 1-2 days before travel and continuing for 4 weeks after returning.
Elderly
No specific dosage adjustment required in the elderly, but caution should be exercised in patients with significant hepatic impairment.
Renal_impairment
No dosage adjustment needed as doxycycline is primarily excreted via non-renal routes. However, caution is advised in severe renal impairment.
How to Take
Take with a full glass of water (approx. 240 mL), preferably while sitting or standing, to reduce the risk of esophageal irritation and ulceration. Do not lie down for at least 30-60 minutes after taking the capsule. Can be taken with food if stomach upset occurs, but avoid dairy products, antacids, and iron preparations within 2 hours of taking doxycycline.
Mechanism of Action
Doxycycline inhibits bacterial protein synthesis by reversibly binding to the 30S ribosomal subunit, thereby preventing the attachment of aminoacyl tRNA to the A site on the ribosome. This action is primarily bacteriostatic.
Pharmacokinetics
Onset
Antibacterial effects typically begin within hours, with clinical improvement observed over days depending on the infection.
Excretion
Primarily excreted unchanged in feces via intestinal secretion. A smaller portion (30-60%) is excreted in urine. Renal impairment has little effect on its elimination.
Half life
Approximately 16-22 hours, allowing for once or twice-daily dosing.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract (about 90-100%). Peak plasma concentrations are achieved within 2-3 hours. Food and milk products slightly decrease absorption.
Metabolism
Partially metabolized in the liver to inactive metabolites; about 20% of the dose is excreted as inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to doxycycline or other tetracyclines
- •Pregnancy (especially second and third trimesters) due to risk of permanent tooth discoloration and bone growth inhibition in fetus
- •Children under 8 years of age (due to risk of permanent tooth discoloration and bone growth inhibition)
- •Severe hepatic impairment
Drug Interactions
Penicillins
Tetracyclines may interfere with the bactericidal action of penicillins. Avoid concomitant use if possible.
Methotrexate
Doxycycline may increase the plasma concentration of methotrexate. Monitor for increased toxicity.
Oral contraceptives
May reduce the effectiveness of oral contraceptives. Advise patients to use an additional non-hormonal method of contraception.
Oral anticoagulants (e.g., Warfarin)
Doxycycline may enhance the anticoagulant effect. Monitor INR/PT closely.
Barbiturates, Carbamazepine, Phenytoin
These drugs can induce hepatic enzymes, leading to increased metabolism and decreased half-life of doxycycline, potentially reducing its efficacy.
Antacids (containing aluminum, calcium, magnesium), iron supplements, bismuth subsalicylate, zinc supplements
These bind to doxycycline and reduce its absorption. Separate administration by at least 2-3 hours.
Storage
Store below 30°C (86°F) in a dry place, away from direct light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, and potentially severe esophageal irritation. In severe cases, hepatic dysfunction may occur. Management involves gastric lavage, supportive care, and symptomatic treatment. Doxycycline is not readily removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category D. Doxycycline crosses the placenta and can cause permanent discoloration of teeth (yellow-gray-brown) and inhibition of bone growth in the fetus if used during the second and third trimesters. Avoid during pregnancy. Doxycycline is excreted into breast milk. Although data suggest minimal absorption by the infant, it's generally advised to avoid during lactation due to potential for dental staining and effects on bone development.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the manufacturing date, consult the specific packaging for exact details.
Availability
Pharmacies, hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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