Vilaro
Generic Name
Indacaterol
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| vilaro 25 mcg inhalation capsule | ৳ 70.00 | N/A |
Description
Overview of the medicine
Vilaro 25 mcg Inhalation Capsule contains Indacaterol, a long-acting beta2-adrenergic agonist (LABA), used for the maintenance treatment of chronic obstructive pulmonary disease (COPD) in adults. It helps to relax the muscles around the airways in the lungs, making it easier to breathe.
Uses & Indications
Dosage
Adults
One 75 mcg capsule once daily, or 25 mcg (for maintenance) once daily, inhaled using the specific inhaler device. Always follow your doctor's instructions.
Elderly
No dose adjustment is required in elderly patients.
Renal_impairment
No dose adjustment is required in patients with renal impairment.
How to Take
For oral inhalation only. The capsule should be placed into a specific inhaler device (e.g., Breezhaler or similar) and the powder inhaled through the mouth. Do not swallow the capsule.
Mechanism of Action
Indacaterol is a potent and ultra-long-acting beta2-adrenergic agonist. It stimulates beta2-adrenergic receptors in the smooth muscle of the bronchi, leading to bronchodilation. This relaxes the airway muscles, helping to open up the airways and improve airflow.
Pharmacokinetics
Onset
Within 5 minutes
Excretion
Mainly via feces (94%), with a small amount excreted in urine (less than 2%).
Half life
Approximately 40-56 hours
Absorption
Rapidly absorbed after oral inhalation, reaching peak plasma concentrations within 15-30 minutes.
Metabolism
Primarily metabolized by UGT1A1 and CYP3A4 enzymes.
Side Effects
Contraindications
- Hypersensitivity to indacaterol or any component of the formulation.
- Acute bronchospasm (not indicated for rescue therapy).
Drug Interactions
Beta-blockers
May reduce the effect of indacaterol and cause severe bronchospasm in COPD patients.
Other sympathomimetics
May potentiate the adverse effects of indacaterol.
Diuretics (loop or thiazide)
May potentiate hypokalemia.
Tricyclic antidepressants, MAO inhibitors
May potentiate the effect of indacaterol on the cardiovascular system.
CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
May increase indacaterol exposure.
Storage
Store in a cool, dry place, below 30°C. Protect from moisture and light. Keep out of reach of children.
Overdose
Symptoms of overdose include tachycardia, tremors, palpitations, headache, nausea, and vomiting. Treatment is symptomatic and supportive. Cardiac monitoring may be necessary.
Pregnancy & Lactation
Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown if indacaterol is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Patent expired for original formulation; generics available
Clinical Trials
Extensive clinical trials (e.g., INHANCE, INLIGHT, ILLUMINATE) have demonstrated the efficacy and safety of indacaterol in COPD patients, showing significant improvement in lung function and reduction in exacerbations.
Lab Monitoring
- Monitor for signs of cardiovascular effects (e.g., heart rate, blood pressure).
- Monitor for hypokalemia and hyperglycemia, especially in susceptible patients.
Doctor Notes
- Emphasize proper inhaler technique to patients.
- Monitor patients for worsening COPD symptoms or cardiovascular adverse events.
- Not for acute symptom relief.
Patient Guidelines
- Use the inhaler exactly as prescribed by your doctor.
- Do not swallow the capsules.
- Rinse your mouth with water after each use to reduce the risk of oral thrush.
- If you experience worsening breathing or symptoms, seek medical attention immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Indacaterol is unlikely to affect the ability to drive or operate machinery. However, if you experience side effects like dizziness, caution is advised.
Lifestyle Advice
- Avoid smoking.
- Maintain a healthy diet and regular exercise as advised by your doctor.
- Stay hydrated.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.